撞击流环隙喷嘴在超临界流体技术制备药物超微颗粒中的应用研究  

Study on the application of impinging flow annular gap nozzle in supercritical fluid technology for the preparation of drug ultrafine particles

作　　者：郝明洁 胡德栋[1] 陈晓娜 HAO Mingjie;HU Dedong;CHEN Xiaona(School of Mechanical and Electrical Engineering,Qingdao University of Science and Technology,Qingdao 266061,China;Lunan Pharmaceutical Group Corporation,Linyi 276005,China)

机构地区：[1]青岛科技大学机电工程学院,山东青岛266061 [2]鲁南制药集团股份有限公司,山东临沂276005

出　　处：《能源化工》2020年第4期45-50,共6页Energy Chemical Industry

摘　　要：以撞击流环隙喷嘴为核心设备,研制了SFPP-50-50型超临界流体药物颗粒制备装置,探究撞击流环隙喷嘴制备药物超微颗粒的工艺参数,为进一步优化喷嘴结构提供试验数据和理论基础。以银杏叶提取物为原料,利用超临界CO2抗溶剂技术,采用曲面响应法分析试验数据,考察了反应温度、反应压力和反应物质量浓度对银杏叶提取物粒径的影响。结果表明:以撞击流环隙喷嘴为核心设备,利用超临界流体CO2抗溶剂技术,能够制备出粒径较小,形状规则均匀的银杏叶提取物颗粒;在反应温度40℃、反应压力13 MPa、反应物质量浓度20 g/L的条件下,制备的银杏叶提取物粒径能达到8μm左右,且制备的产品晶型良好,颗粒分布较均匀,反应前后银杏叶提取物物理化学性质和结构没有明显的变化。Taking impinging stream nozzles with annulus as the core equipment,a SFPP-50-50 supercritical fluid drug particle preparation device is developed to explore the process parameters of impinging flow annular gap nozzle for preparing drug ultra-fine particles,and provide experimental data and theoretical basis for further optimizing of nozzle structure.With ginkgo biloba extract(GBE)as raw material,using supercritical CO2 anti-solvent technology,surface response method to analyze experimental data,the effects of reaction temperature,reaction pressure and reactant mass concentration on the GBE particle size are investigated.The results show that with the impinging nozzle as the core device,using supercritical fluid CO2 solvent resistant technology,the GBE particles with small and uniform size and regular shape can be prepared.Under the conditions of reaction temperature 40℃,reaction pressure13 MPa and reactant mass concentration 20 g/L,the particle size can reach about 8μm,and the crystal shape is good,the particle size distribution is uniform.The physical and chemical properties and structure of GBE particles before and after reaction have no obvious change.

关 键 词：撞击流环隙喷嘴 超临界流体技术 药物颗粒 银杏叶提取物 

分 类 号：TQ460.5[化学工程—制药化工]