自身免疫性胶质纤维酸性蛋白星型细胞病的脑电图特点  

Clinical feature and electroencephalogram characteristics of autoimmune glial fibrillary acidic protein(GFAP)astrocytopathy

作　　者：黄莉[1] 李惠璐 龙友明[1] 高聪[1] 杨华才 刘思 杨容坤[1] HUANG Li;LI Huilu;LONG Youming;GAO Cong;YANG Huacai;LIU Si;YANG Rongkun(Department of Neurology,the Second Affiliated Hospital of Guangzhou Medical University,Guangzhou 510260,China)

机构地区：[1]广州医科大学附属第二医院神经内科,广州510260

出　　处：《实用医学杂志》2020年第19期2700-2704,共5页The Journal of Practical Medicine

基　　金：国家自然科学基金项目(编号:81771302);广州市民生科技攻关项目(编号:201803010123)。

摘　　要：目的探讨自身免疫性GFAP星型细胞病的脑电图(electroencephalographic,EEG)的特点。方法对确诊自身免疫性GFAP星型细胞病患者的临床和脑电图等资料进行回顾性分析。分析不同临床表现患者脑电图、头MR影像特点,随访3~12个月。结果共纳入自身免疫性GFAP星型细胞病患者38例,主要临床表现包括肢体乏力、麻木(n=20,52.6%)、发热(n=14,42.1%)、头痛(n=16,42.1%)、排便障碍(n=9,23.7%)、癫痫发作(n=5,13.2%)。26例患者有效脑电图记录中3例可见各导联弥漫性慢活动出现,5例出现癫痫样放电,9例出现散在慢波,9例正常脑电图。结论EEG对自身免疫性GFAP星型细胞病的诊断、追踪随访及预后评估有实用意义。Objective The purpose of this study was to explore the characteristics of clinical manifestation,electroencephalographic(EEG)and magnetic resonance imaging(MRI)of autoimmune glial fibrillary acidic protein(GFAP)astrocytopathy.Methods The clinical data of 38 patients with autoimmune GFAP astrocytopathy were retrospectively analyzed.Diagnosis of these patients were confirmed by antibody detection in CSF.All the clinical data,including clinical manifestation,MRI and EEG were carefully analyzed.The follow-up were carried out lasted 3 to 12 months.Results Among the patients,16 of them had headache,20 had weakness and numbness of limbs.9 of the them had abnormal defecation.14 of the them had fever.5 of them suffered from seizure.Effective EEGs were collected in 26 patients.The abnormal EEGs mainly showed diffuse slow waves in 3 patients,epileptiform discharges in 5 patients,slow waves scattered in 9 patients and 9 of them showed normal in EEG.Conclusion Electroencephalogram is an important method for the evaluation of GFAP astrocytopathy.

关 键 词：自身免疫性GFAP星型细胞病 自身免疫性 脑电图 癫痫 

分 类 号：R444[医药卫生—诊断学]