热休克蛋白90与肺癌相关性研究进展  

Research Advances in Relevance of Heat Shock Protein 90 with Lung Cancer

作　　者：陈欣[1,2,3] 戈海泽 CHEN Xin;GE Hai-ze(Third Central Hospital of Tianjin,Tianjin,300170,China)

机构地区：[1]天津市第三中心医院,天津300170 [2]天津市人工细胞重点实验室,天津300170 [3]卫生部人工细胞工程技术研究中心,天津300170

出　　处：《黑龙江医学》2020年第10期1467-1469,共3页Heilongjiang Medical Journal

摘　　要：热休克蛋白90(Heat shock protein 90,HSP90)是热休克蛋白家族中在遗传上高度保守的成员之一,HSP90作为一种分子伴侣,主要功能是参与蛋白翻译后的正确折叠加工。近年来研究发现肿瘤细胞中HSP90呈现明显的高表达,并在肺癌的发生发展以及侵袭转移中都发挥着至关重要的作用。本文就HSP90与肺癌相关性的研究进展以及其抑制剂用于肺癌治疗的研究现状做一综述。Heat shock protein 90(HSP90)is one of the genetically highly conserved HSP members.As a molecular chaperone,HSP90 plays an important role in assisting its substrate proteins to fold correctly.Level of HSP 90 in cancer cells is found higher than that in normal ones in recent years,and it plays a crucial role in the development and progression of lung cancer.The paper summarizes recent studies referring to the correlation of HSP90 with lung cancer and the research status of HSP90 inhibitors for lung cancer treatment.

关 键 词：热休克蛋白90 肺癌 抑制剂 

分 类 号：R283[医药卫生—中药学]