环状RNAs——抗病毒免疫新靶标  

Circular RNAs: new targets for antiviral immunity

作　　者：徐嘉欣 李连峰[2] 曹宏伟[1] 仇华吉[2] XU Jiaxin;LI Lianfeng;CAO Hongwei;QIU Huaji(College of Life Science and Technology,Heilongiang Bayi Agricultural University,Daqing 163316,China;State Key Laboratory of Veterinary Biotechnology,Harbin Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Harbin 150069,China)

机构地区：[1]黑龙江八一农垦大学生命科学技术学院,大庆163316 [2]中国农业科学院哈尔滨兽医研究所兽医生物技术国家重点实验室,哈尔滨150069

出　　处：《生命的化学》2020年第8期1346-1352,共7页Chemistry of Life

基　　金：国家自然科学基金青年项目(31702220);黑龙江省自然科学基金联合引导项目(LH2019C046);黑龙江省科学基金杰出青年项目(JQ2020C002)。

摘　　要：环状RNAs(circular RNAs,circRNAs)是一种内源性非编码RNAs,结构呈闭合环状,不易被核酸外切酶切割,能够稳定存在于所有真核细胞和病毒基因组中。已有研究表明,circRNAs能够诱导天然免疫相关基因的表达,参与宿主抗病毒免疫应答,保护宿主免受病毒感染。此外,宿主抗病毒免疫相关因子(如NF90/NF110)通过调控circRNAs的形成,进而发挥抗病毒功能。因此,本文总结了circRNAs的特征、作用机制及其生物学功能,并重点讨论其在宿主抗病毒免疫中的作用,旨在为病毒与宿主互作机制提供新的研究方向。Circular RNAs(circRNAs)are a kind of endogenous noncoding RNAs,with closed loop structure that is not easily cleaved by exonuclease,and they can be stably present in all eukaryotic cells and viral genomes.Previous studies have shown that circRNAs can induce the expression of antiviral genes,which is participated in the host antiviral immune responses and protected the host from virus infections.In addition,the host antiviral immune related factors(such as NF90/NF110)participate in the antiviral immune response through promoting circRNA biogenesis.This review summarized the characteristics,mechanisms and biological functions of circRNAs,and focused on the roles of circRNAs in host defense against viral infection,which is expected to provide a new research directions for the mechanism of virus-host interactions.

关 键 词：环状RNAs 病毒感染 抗病毒免疫 病毒与宿主互作 

分 类 号：R392[医药卫生—免疫学]