发酵支原体MALP-2生物学作用研究进展  

The progress of immunologic mechanisms of mycoplasma fermentans macrophage-activating lipopeptide-2

作　　者：梁珂莹 刘君[1,2] 曾焱华 何军 LIANG Keying;LIU Jun;ZENG Yanhua;HE Jun(Department of Clinical Laboratory,Nanhua Affiliated Hospital,University of South China,Hengyang 421002,Hunan,China;Institute of Pathogenic Biology,Hengyang Medical College,University of South China,Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control,Hengyang 421001,Hunan,China)

机构地区：[1]南华大学附属南华医院检验科,湖南衡阳421002 [2]南华大学衡阳医学院病原生物学研究所,特殊病原体防控湖南省重点实验室,湖南衡阳421001

出　　处：《中南医学科学杂志》2020年第5期449-453,共5页Medical Science Journal of Central South China

基　　金：国家自然科学基金资助项目(31100137);湖南省自然科学基金资助项目(2018JJ6072);湖南省卫生健康委科研重点课题(20201915)。

摘　　要：巨噬细胞活化脂肽-2(MALP-2)是发酵支原体(Mf)上极具代表性的外膜脂肽,N端为特殊的二酰化半胱氨酸残基结构。MALP-2是一把"双刃剑",在致炎与抗炎、细胞凋亡与抗凋亡、免疫佐剂、生物协同与抑制、血管损伤和血管修复等方面发挥重要作用。因此,了解MALP-2复杂的生物学作用能为理解Mf的致病机制及其临床治疗方案提供依据,同时也为MALP-2的临床应用提供理论基础。Macrophage-activating lipopeptide-2(MALP-2)is a classical mycoplasma-derived outer membrane lipopeptide on Mycoplasma fermentans(Mf)with a special diacylated cysteine residue structure at the N-terminal.MALP-2 poses as a double-edged sword that plays an important role in inflammation and anti-inflammation,apoptosis and anti-apoptosis,immune adjuvant,biological synergy,biological inhibition,vascular injury and vascular repair,etc.Therefore,making out the complex immunologic mechanisms of MALP-2 can provide a basis for understanding the pathogenesis of Mf and its clinical treatment,which also provides a theoretical basis for the clinical application of MALP-2.

关 键 词：发酵支原体 巨噬细胞活化脂肽-2 生物学作用 致病机制 

分 类 号：R375.3[医药卫生—病原生物学]