神经内分泌在多囊卵巢综合征发病机制中的研究进展  

Research Progress of Neuroendocrine in the Pathogenesis of Polycystic Ovary Syndrome

作　　者：杜晓琴[1] 刘美玉[1] 尹菊(审校)[1] DU Xiao-qin;LIU Mei-yu;YIN Ju(Tianjin Central Hospital of Gynecology Obstetrics,Tianjin 300100,China)

机构地区：[1]天津市中心妇产科医院,300100

出　　处：《国际妇产科学杂志》2020年第5期503-507,共5页Journal of International Obstetrics and Gynecology

基　　金：天津市卫生健康委员会、天津市中医药管理局中医中西医结合科研课题(2019104)。

摘　　要：多囊卵巢综合征(PCOS)是最常见的女性生殖障碍疾病,影响全球育龄期女性,发病机制尚未明确。研究发现神经内分泌疾病患者PCOS的发生率较高,PCOS患者脑脊液γ氨基丁酸(GABA)和血液Kisspeptin水平升高,Neurokinin B受体(NK3R)拮抗剂治疗后,PCOS患者睾酮和黄体生成激素(LH)水平下降,提示神经内分泌紊乱是PCOS的发病机制之一。常用的PCOS动物模型包括产前雄激素模型、产前抗苗勒管激素(AMH)模型、产后雄激素模型和芳香化酶抑制剂模型。不同模型模拟了PCOS的不同亚型,其中芳香化酶抑制剂模型较好地反映了PCOS的神经内分泌改变。临床及动物模型研究显示促性腺激素释放激素(GnRH)神经元、GABA能神经元、Kisspeptin神经元和雄激素等参与了PCOS的神经内分泌调节。PCOS is the most common female reproductive disorder and affects women of childbearing age worldwide.The pathogenesis is not clear.Studies have found that patients with neuroendocrine diseases are associated with a higher incidence of PCOS.The levels of GABA and blood Kisspeptin were increased in patients with PCOS.The levels of testosterone and LH in patients with PCOS are reduced after NK3R antagonists,suggesting that neuroendocrine disorders are one of the pathogenesis of PCOS.Commonly used animal models of PCOS include prenatal androgen model,prenatal AMH model,postpartum androgen model and aromatase inhibitor model.Different models simulate different subtypes of PCOS,and the aromatase inhibitor model reflected the neuroendocrine changes of PCOS better.Clinical and animal models show that GnRH neurons,GABAergic neurons,Kisspeptin neurons and androgens are involved in the regulation of PCOS neuroendocrine.This article reviews the research progress of neuroendocrine in the pathogenesis of PCOS.

关 键 词：多囊卵巢综合征 神经分泌系统 神经内分泌细胞 Γ氨基丁酸 促性腺素 

分 类 号：R711.75[医药卫生—妇产科学]