德宏州2015-2018年HIV感染者阴性配偶HIV新发感染及其影响因素  

Incidence and risk factors of HIV infection among HIV-negative spouses living with HIV-positive spouses during 2015-2108 in Dehong,Yunnan

作　　者：曹艳芬[1] 李自慧 杨跃诚[1] 王继宝[1] 杨世江[1] 唐仁海[1] 何纳[2] 段松[1] CAO Yanfen;LI Zihui;YANG Yuecheng;WANG Jibao;YANG Shijiang;TANG Renhai;HE Na;DUAN Song(Dehong Prefecture Center for Disease Control and Prevention,Mangshi 678400,China;School of Public Health,Fudan University,Key Laboratory of Public Health Safety,Ministry of Education,Shanghai 200032)

机构地区：[1]德宏州疾病预防控制中心,云南芒市678400 [2]复旦大学公共卫生学院,上海200032

出　　处：《中国艾滋病性病》2020年第9期966-969,973,共5页Chinese Journal of Aids & STD

基　　金：国家科技重大专项(2018ZX10715006-001,2018ZX 10721102-004);国家重点地区艾滋病防治项目。

摘　　要：目的了解2015-2018年德宏州艾滋病病毒(HIV)感染者阴性配偶队列HIV新发感染及其影响因素。方法德宏州HIV感染者阴性配偶前瞻性研究队列每年随访一次,收集研究对象的行为特征以及HIV新发感染等信息。统计分析2015-2018年队列人群HIV新发感染率,并对新发感染的危险因素进行COX多因素回归分析。结果德宏州2015-2018年HIV感染者阴性配偶的新发感染率为0.40/100人年,历年新发感染率依次为0.31/100人年、0.36/100人年、0.54/100人年、0.26/100人年。COX生存分析发现年龄<30岁、男性、除傣族以外的少数民族是HIV感染者阴性配偶新发感染的危险因素。结论2015-2018年德宏州HIV感染者阴性配偶的新发感染率处于较低水平,应继续保持对HIV单阳家庭的健康教育、检测咨询、安全套推广使用以及及早抗病毒治疗等有效的预防干预措施,持续降低HIV家庭内二次传播。Objective This study is to investigate the rate of HIV infection among HIV-serodiscordant couples during 2015-2018 as well as the influential factors of their new infection.Methods A prospective and dynamic cohort study was conducted among HIV-negative spouses with HIV-infected spouses.These spouses were followed up annually to collect the information about baseline,sexual behaviors and HIV serostatus.Results The incidence of HIV infection in all HIV-uninfected spouses with HIV-infected spouse was 0.40/100 PYS during 2015-2018.The rate of incidence in males and females was 0.34/100 PYS and 0.43/100 PYS,respectively.We found that those characterized by male,aged<30,residence in Dehong other than Ruili and ethnic minority other than Yi group were more likely to be infected with HIV.Conclusion From 2015 to 2018,the incidence of HIV-negative spouses in Dehong is low.It is of significant necessity to strengthen the ability of HIV-serodiscordant couples to prevent HIV transmission by health education.Additionally,we still need to promote the use of condom and voluntary counselling and testing for HIV prevention.

关 键 词：艾滋病 阴性配偶 新发感染率 危险因素 

分 类 号：R512.91[医药卫生—内科学] R373.9[医药卫生—临床医学]