HIV-1附属蛋白在HIV-1/HCV共感染中的作用及研究进展  

Role of HIV-1 accessory protein in HIV-1/HCV co-infection and the research progress

作　　者：周正萍 黄文昶 邹薇[2] ZHOU Zhengping;HUANG Wenchang;ZOU Wei(Nanchang University,Nanchang 330006,China;The First Affiliated Hospital of Nanchang University,Nanchang 330006)

机构地区：[1]南昌大学,南昌330006 [2]南昌大学第一附属医院,南昌330006

出　　处：《中国艾滋病性病》2020年第9期1021-1024,共4页Chinese Journal of Aids & STD

基　　金：国家自然科学基金(86660279,81701629);江西省科学技术厅(20161ACB21016,20171BCB23088,20181ACH80002);中国教育部为留学回国学者提供的启动资金(2015060020102070)。

摘　　要：当前,全世界丙型肝炎病毒(HCV)慢性感染病例人数已从1.7亿增加到1.85亿。同时,大约有400万~500万的HCV感染病例感染了艾滋病病毒(HIV)。许多研究发现,HIV-1/HCV共感染患者中的HIV-1可以通过多种途径加速HCV感染的进程,从而增加肝纤维化和肝癌的风险。最重要的是,共感染中HIV-1的6个附属蛋白:Tat,Rev,Vif,Vpr,Vpu和Nef,在促进病毒增殖、诱导免疫抑制和细胞死亡中起着重要作用。本文着重于阐述HIV-1的6个附属蛋白在HIV-1/HCV共感染的发病机理中的作用。Currently,the number of patients with chronic hepatitis C infection worldwide has risen from 170 million to 185 million.At the same time,about 4 to 5 million of hepatitis C patients are infected with human immunodeficiency virus.Many studies have found that HIV-1 in HIV-1/HCV co-infected patients can accelerate the progress of HCV infection through a variety of pathways,resulting in an increased risk of liver fibrosis and liver cancer.Most importantly,the six accessory proteins of HIV-1:Tat,Rev,Vif,Vpr,Vpu and Nef,play an important role in promoting viral proliferation,inducing immunosuppression and cell death in HIV-1/HCV co-infection.This review focuses on the role of the six accessory proteins of HIV-1 in the pathogenesis of HIV-1/HCV co-infection.

关 键 词：1型艾滋病病毒/丙型肝炎病毒 TAT蛋白 Rev蛋白 Vif蛋白 Vpr蛋白 Vpu蛋白 NEF蛋白 

分 类 号：R512.91[医药卫生—内科学] R373.9[医药卫生—临床医学]