慢性阻塞性肺疾病急性加重期患者血清sTREM-1、suPAR、sICAM-1水平及与病情程度的相关性  

The level of serum sTREM-1,suPAR and sICAM-1 in patients with acute exacerbation of chronic obstructive pulmonary disease and its correlation with the disease condition

作　　者：何海栋 柴秀娟[1] 徐卫华[1] 周颖[1] 许先荣[1] Hai-dong He;Xiu-juan Chai;Wei-hua Xu;Ying Zhou;Xian-rong Xu(Department of Respiratory Medicine,Zhejiang Provincial Tongde Hospital,Hangzhou,Zhejiang 310012,China)

机构地区：[1]浙江省立同德医院呼吸内科,浙江杭州310012

出　　处：《中国现代医学杂志》2020年第20期78-81,共4页China Journal of Modern Medicine

摘　　要：目的探讨慢性阻塞性肺疾病急性加重期(AECOPD)患者血清可溶性髓细胞触发受体-1(sTREM-1)、可溶性尿激酶型纤溶酶原激活物受体(suPAR)、可溶性细胞间黏附分子-1(sICAM-1)水平及与病情程度的相关性。方法选取2018年1月-2019年8月浙江省立同德医院收治的AECOPD患者68例作为AECOPD组。另取同期该院42例COPD患者作为COPD组,42例健康体检者作为对照组。检测3组一秒用力呼气容积(FEV1),并计算第一秒用力呼气容积占预计值百分比(FEV1%pred)。采用酶联免疫吸附试验检测3组血清sTREM-1、suPAR、sICAM-1水平。分析AECOPD组血清sTREM-1、suPAR、sICAM-1与FEV1%pred的相关性。结果 3组血清sTREM-1、suPAR、sICAM-1水平比较,经方差分析,差异均有统计学意义(P<0.05);COPD组和AECOPD组高于对照组(P<0.05)。AECOPD组高于COPD组(P<0.05)。Pearson相关性分析显示,AECOPD患者血清sTREM-1、suPAR、sICAM-1与FEV1%pred均呈负相关(r=-0.868、-0.911和-0.908,P<0.05)。结论 AECOPD患者血清sTREM-1、suPAR、sICAM-1水平升高,且其水平越高,FEV1%pred越低。sTREM-1、suPAR、sICAM-1可以作为早期诊断AECOPD病情程度的指标。Objective To investigate the level of serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1),soluble urokinase-type plasminogen activator receptor (suPAR) and soluble intercellular adhesion molecule-1 (sICAM-1) in patients with acute exacerbation of chronic obstructive pulmonary disease and its correlation with the disease condition.Methods Sixty-eight patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) admitted to our hospital from January 2018 to August 2019 were selected as the AECOPD group.In the same period,42 patients with stable chronic obstructive pulmonary disease (COPD) were selected as the stable COPD group,and 42 healthy subjects were enrolled as the control group.The forced expiratory volume in one second (FEV1) and FEV1 percentage predicted (FEV1%pred) were examined and calculated.Serum sTREM-1,suPAR,and sICAM-1 levels were detected by ELISA,and the differences among the groups were compared.Pearson correlation analysis was used to investigate the relationship between serum sTREM-1,suPAR and sICAM-1 levels and indicators of pulmonary function.Results The serum sTREM-1,suPAR and sICAM-1 levels among the three groups were all significantly different (P<0.05),and those in the stable COPD group and AECOPD group were higher than those in the control group (P<0.05).Furthermore,compared with stable COPD group,serum sTREM-1,suPAR and sICAM-1 levels were higher in AECOPD group (P<0.05).Pearson correlation analysis showed that serum sTREM-1 (r=-0.868),suPAR (r=-0.911),and sICAM-1 (r=-0.908) levels in patients with AECOPD were negatively correlated with FEV1%pred (P<0.05).Conclusions The serum levels of sTREM-1,suPAR and sICAM-1 are increased in AECOPD patients.Moreover,the higher are the levels of sTREM-1,suPAR and sICAM-1,the lower is FEV1%pred,which can be used as an index for indicating the disease condition of AECOPD.

关 键 词：慢性阻塞性肺疾病急性加重期/肺疾病 慢性阻塞性 可溶性髓细胞触发受体-1/受体 可溶性尿激酶型纤溶酶原激活物受体/受体 可溶性细胞间黏附分子-1 相关性 

分 类 号：R563[医药卫生—呼吸系统]