四川南部地区人类浅部真菌病的分子流行病学调查  

Molecular Epidemiological Study on Human Superficial Mycosis in Southern Sichuan

作　　者：何香燕 潘应浩 周霖 周梅 邓永琼 熊霞 He Xiangyan;Pan Yinghao;Zhou Lin(The Affiliated Hospital of Southwest Medical University,Luzhou,Sichuan 646000,China)

机构地区：[1]西南医科大学附属医院,四川泸州646000

出　　处：《四川医学》2020年第9期984-989,共6页Sichuan Medical Journal

摘　　要：目的了解四川南部地区人群浅部真菌病的致病菌种构成及其流行情况,为本地区浅部真菌病的防治提供指导。方法对2018年8月至11月就诊于四川南部地区三家医院门诊部,且临床拟诊为浅部真菌病的患者进行真菌镜检、培养,分子生物学鉴定菌种,临床资料收集。结果共收集251例皮屑标本,经实验室真菌培养和鉴定,共检测出215份真菌阳性标本。病种以股癣(42.8%)为主,体癣(21.9%)和足癣(17.2%)次之;致病菌种以皮肤癣菌(58.1%)为主,主要包括红色毛癣菌114株(53.0%)为主,犬小孢子菌7株(3.3%),趾间毛癣菌4株(1.9%);其次为念珠菌属(16.3%),主要包括近平滑念珠菌11株(5.1%),白念珠菌11株(5.1%),热带念珠菌10株(4.7%),季也蒙念珠菌2株(0.9%)和平滑念珠菌1株(0.5%)。统计学分析显示,不同性别、年龄、病程在浅部真菌病的发病存在一定的差异;红色毛癣菌感染与病程(r=0.194,P=0.004)呈正相关。结论四川南部地区浅部真菌病以股癣为主,体癣和足癣次之,主要致病菌仍为红色毛癣菌,念珠菌属次之。Objective To understand the composition and prevalence of pathogenic bacteria of superficial mycosis in southern Sichuan,and provide guidance for local prevention and treatment.Methods From August to November 2018,fungal microscopy,culture,molecular biological identification of bacterial strains,and clinical data collection were carried out on patients who were in outpatient department of three hospitals in southern Sichuan and were clinically diagnosed as superficial mycoses.Results A total of 251 dander specimens were collected.According to laboratory fungal culture and identification,215 fungal positive specimens were detected.Tinea corporis(42.8%)was the main disease type,followed by tinea corporis(21.9%)and tinea pedis(17.2%).The pathogenic bacteria were mainly dermatophytes(58.1%).It mainly includes 114 strains(53.0%)of trichophyton rubrum,7 strains(3.3%)of microsporum canis,and 4 strains(1.9%)of trichophyton interdigita.The second was candida(16.3%),mainly including 11 candida parapsilosis(5.1%),11 candida albicans(5.1%),10 candida tropicalis(4.7%),and2 candida jiyemeng(0.9%)and 1 strain(0.5%)of candida pleuratus.Statistical analysis shows that there were certain differences in the incidence of superficial mycoses in different genders,ages,and course of disease.Trichophyton rubrum infection was positively correlated with the course of disease(r=0.194,P=0.004).Conclusion In southern Sichuan,tinea cruris is the main superficial fungal disease,followed by tinea corporis and tinea pedis.The main pathogen is still trichophyton rubrum,followed by candida.

关 键 词：浅部真菌病 分子流行病学 致病菌种 红色毛癣菌 

分 类 号：R756[医药卫生—皮肤病学与性病学]