基于纳米颗粒的化学发光技术在炎症及肿瘤诊疗中的应用  

Application of Nanoparticles-Based Chemiluminescence in Diagnosis and Treatment of Inflammation and Tumor

作　　者：丁静静 黄利利[1] 谢海燕[1] Ding Jingjing;Lili Huang;Haiyan Xie(School of Life Science,Beijing Institute of Technology,Beijing 100081,China)

机构地区：[1]北京理工大学生命学院,北京100081

出　　处：《化学进展》2020年第9期1252-1263,共12页Progress in Chemistry

基　　金：国家自然科学基金项目(No.21874011)资助。

摘　　要：光学技术在生物医药领域具有至关重要的作用,它不仅使生物活体的检测变得可视化,还可以提高疾病治疗的特异性和灵敏性。但是普通的光学技术具有组织穿透深度低、信噪比低和组织自发光等问题。针对这些问题,研究者开始关注并研究自发光技术,包括化学发光、生物发光、切伦科夫发光。其中,化学发光(Chemiluminescence,CL)是化学物质在进行化学反应过程中产生的一种光辐射现象,具有灵敏度高、无需外部光源激发、打破组织穿透深度限制、提高信噪比的优势,为光学成像与治疗技术的进一步发展提供了新思路。但是由于化学发光物质的疏水性等问题限制了其在生物医药领域的应用。针对这些问题,研究者开始将纳米技术与化学发光技术进行结合,不仅拓展了化学发光的应用范围,还进一步促进了疾病的诊断与治疗。在此基础上,该文首先分析了化学发光的分子机理,其次总结归纳了化学发光在炎症及肿瘤诊疗中的应用,并探讨了在实际应用中遇到的问题以及未来的发展方向。Optical technology plays a vital role in the field of biomedicine.It not only enables visualization of physiological or pathological processes at the cellular and subcellular dimensions in living subjects,but also improves the specificity and sensitivity of disease treatment.However,ordinary optical technology faces many challenges,including relatively low tissue penetration depth,low signal-to-noise ratio,and autofluorescence of the tissue.To overcome these problems,many researchers have gradually begun to focus on self-luminous technologies,including chemiluminescence,bioluminescence,and Cherenkov luminescence.Among them,chemiluminescence(CL)is a kind of light radiation phenomenon,which is produced by chemical substances in the process of chemical reactions.It has many advantages,including high sensitivity,no need for external light source excitation,breaking through the limit of tissue penetration depth,and improving the signal-to-noise ratio.These characteristics provide new ideas for the further development of optical imaging and treatment technology.However,due to the hydrophobicity of the chemiluminescent substance and other problems,its application in the field of biomedicine has been limited.To solve these problems,researchers have begun to combine nanotechnology with chemiluminescence technology,which not only expands the application range of chemiluminescence,but also further promotes the diagnosis and treatment of diseases.On this basis,the article first analyzes the molecular mechanism of chemiluminescence,secondly summarizes the application of chemiluminescence in the diagnosis and treatment of inflammation and tumor,and discusses the problems encountered in practical applications and the future development direction.

关 键 词：化学发光 鲁米诺 过氧化草酸酯 过氧化氢 纳米颗粒 成像 治疗 

分 类 号：O65[理学—分析化学] O69[理学—化学]