斑马鱼作为模式动物在人类眼睛疾病研究中的应用  

Application of Zebrafish as A Model Animal in Research of Human Eye Diseases

作　　者：邸亚男 朱丽英 钱雯 潘卫 DI Yanan;ZHU Liying;QIAN Wen;PAN Wei(Clinical Laboratory in Beifang Section of Peking University Third Hospital,Beijing 100089,China;School of Clinical Laboratory Science,Guizhou Medical University,Guiyang 550025,China;Guizhou Prenatal Diagnosis Center,Afftli ated Hospital of Guizhou Medical University,Guiyang 550025,China;Key Laboratory of Environmental Pollution and Disease Monitoring,Ministry of Education,Guizhou Medical University,Guiyang 550025,China)

机构地区：[1]北京大学第三医院北方院区检验科,北京100089 [2]贵州医科大学医学检验学院,贵阳550025 [3]贵州医科大学附属医院贵州省产前诊断中心,贵阳550025 [4]贵州医科大学环境污染与疾病监控教育部重点实验室,贵阳550025

出　　处：《实验动物与比较医学》2020年第5期440-448,共9页Laboratory Animal and Comparative Medicine

摘　　要：斑马鱼(Zebrafish,Danio rerio)作为一种优良的动物模型已经被广泛用于发育生物学、遗传学和毒理学等研究领域。由于斑马鱼在眼睛形态、解剖结构、基因表达及功能等方面与人类存在极大的相似性,并且具有发育快、体外受精、胚胎透明、易于观察等优势,目前已越来越多地用于眼睛发育及相关疾病如眼睛缺损、青光眼、白内障、视杆视锥细胞变性、糖尿病视网膜病变等的研究。本文综述了斑马鱼眼睛发育及结构,以及作为研究眼睛疾病模型的优缺点,从而探讨斑马鱼在人类眼睛疾病研究中的应用价值。As an excellent animal model,zebrafish(Danio rerio)has been widely used in the fields of developmental biology,genetics,toxicology and so on.Because it is great similar to human in aspect of eye morphology,anatomical structure,gene expression and function,and has advantages on rapid development,sperm reception way,embryo transparency and easy observation,zebrafish has been increasingly used in the study of eye development and related diseases such as eye defect,glaucoma,cataract,rod cone degeneration amd diabetic retinopathy.This article will review the eye development and structure of zebrafish as well as the advantages and disadvantages of zebrafish as a model for the study of eye diseases,which will help to have a more comprehensive understanding of the application value of zebrafish in the research of human eye diseases.

关 键 词：斑马鱼 眼睛发育 眼睛疾病 模式动物 

分 类 号：Q95-33[生物学—动物学]