青岛某烟厂体检 人群不同血脂指标与高尿酸血症关系  

ASSOCIATION BETWEEN BLOOD LIPID PARAMETERS AND HYPERURICEMIA IN WORKERS UNDERGOING PHYSICAL EXAMINATION IN A TOBACCO FACTORY IN QINGDAO,CHINA

作　　者：孙昊 崔静 楚立云[3] SUN Hao;CUI Jing;CHU Liyun(Quality Management Department,Qingdao Special Servicemen Recuperation Center of PLA Navy,Qingdao 266071,China)

机构地区：[1]中国人民解放军海军青岛特勤疗养中心质量管理科,山东青岛266071 [2]青岛市疾病预防控制中心/青岛市预防医学研究院 [3]中国人民解放军第971医院保健三科

出　　处：《青岛大学学报（医学版）》2020年第6期723-726,共4页Journal of Qingdao University(Medical Sciences)

基　　金：青岛市医药科研指导计划项目(2017-WJZD134)。

摘　　要：目的探讨青岛某烟厂健康体检人员三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)及高密度脂蛋白(HDL)等血脂指标与高尿酸血症(HUA)患病的关联,为HUA的防治提供科学依据。方法以青岛某烟厂2019年在海军青岛特勤疗养中心体检、年龄22~58岁的员工988例为研究对象,进行问卷调查、内科检查及实验室生化检测。采用多元线性回归方法分析TG、TC、LDL、HDL等血脂指标与尿酸的相关性,采用Logistic回归方法分析TG、TC、LDL、HDL等血脂指标与HUA的关系。结果 HUA患病率为37.0%,HUA组BMI、尿酸及TG、TC、LDL水平均高于非HUA组(t=3.293~36.868,P<0.01),HDL低于非HUA组(t=-8.709,P<0.01)。多元线性回归分析显示,TG、TC、LDL与尿酸呈正相关(β=4.307~13.259,P<0.01),HDL与尿酸呈负相关(β=-41.990,P<0.01)。多因素Logistic回归分析显示,TG边缘升高、高TG血症均与HUA患病呈正相关(OR=2.51、3.42,P<0.01);TC边缘升高、高胆固醇血症均与HUA患病呈正相关(OR=2.17、2.19,P<0.01);LDL边缘升高与HUA患病呈正相关(OR=1.86,P<0.01);HDL降低与HUA患病风险无关(P>0.05)。结论 TG、TC水平升高与HUA患病风险相关,而LDL仅边缘升高与HUA患病风险相关。ObjectiveTo investigate the association of the blood lipid parameters triglyceride(TG),total cholesterol(TC),low-density lipoprotein(LDL),and high-density lipoprotein(HDL)with the risk of hyperuricemia(HUA)in workers undergoing physical examination in a tobacco factory in Qingdao,China,and to provide a scientific basis for the treatment and treatment of HUA.MethodsIn 2019,a questionnaire survey was performed for 988 employees,aged 22-58 years,from a tobacco factory in Qingdao who underwent physical examination in Qingdao Special Servicemen Recuperation Center of PLA Navy,and related medical examination and laboratory tests were performed.A multivariate linear regression analysis was used to investigate the correlation of the blood lipid parameters(TG,TC,HDL,and LDL)with uric acid,and a logistic regression analysis was used to investigate the association of TG,TC,LDL,and HDL with HUA.ResultsThe prevalence rate of HUA was 37.0%,and compared with the non-HUA group,the HUA group had significantly higher levels of BMC,uric aeid,TG,TC,and LDL(t=3.293-36.868,P<0.01)and a significantly lower level of HDL(t=-8.709,P<0.01).The multivariate linear regression analysis showed that TG,TC,and LDL were positively correlated with uric acid(β=4.307-13.259,P<0.01),and HDL was negatively correlated with uric acid(β=-41.990,P<0.01).The multivariable Logistic regression analysis showed that a borderline increase in TG and hypertriglyceridemia were associated with the risk of HUA(OR=2.51,3.42;P<0.01);a borderline increase in TC and hypercholestero-lemia were associated with the risk of HUA(OR=2.17,2.19;P<0.01);a borderline increase in LDL was associated with the risk of HUA(OR=1.86,P<0.01);a reduction in HDL was associated with the risk of HUA(P>0.05).ConclusionElevated TG and TC levels are associated with the risk of HUA,and only the borderline increase in LDL is significantly associated with the risk of HUA.

关 键 词：高尿酸血症 脂类 体格检查 数据相关性 

分 类 号：R589.9[医药卫生—内分泌] R195.1[医药卫生—内科学]