铁死亡调控机制及其与其他细胞死亡关系的研究进展  

RESEARCH ADVANCES IN THE REGULATORY MECHANISM OF FERROPTOSIS AND ITS RELATIONSHIP WITH OTHER CELL DEATHS

作　　者：马德亮 姜英健[1] 李洪波[1] 张佃良[1] MA Deliang;JIANG Yingjian;LI Hongbo;ZHANG Dianliang(Center of Colon and Rectum,Qingdao Municipal Hospital Affiliated to Qingdao University,Qingdao 266011,China)

机构地区：[1]青岛大学附属青岛市市立医院结直肠外科,山东青岛266011

出　　处：《青岛大学学报（医学版）》2020年第6期750-753,共4页Journal of Qingdao University(Medical Sciences)

基　　金：国家自然科学基金面上项目(81270448,81470890)。

摘　　要：铁死亡是近年来新发现的一种调节性细胞死亡方式,其主要特征是铁离子依赖和脂质过氧化,铁诱导的脂质活性氧(ROS)积聚导致细胞发生过氧化反应。它在形态和生化上与已知的其他调节性细胞死亡类型不同。大量的研究已经证明了铁死亡在人类疾病中的重要性,因此对其调控机制及其与其他调节性细胞死亡关系的探究具有重要意义。本文就这两个方面进行综述,以期为铁死亡相关疾病治疗提供新的研究方向。Ferroptosis is a form of regulated cell death(RCD)newly identified in recent years,which is mainly characte-rized by ferric ion dependence,lipid peroxidation,and cell peroxidation resulting from accumulation of lipid reactive oxygen species induced by iron.It is morphologically and biochemically different from other types of known RCDs.Numerous studies have demonstrated the importance of ferroptosis in human diseases.Therefore,it is of great significance to investigate its regulatory mechanism and its relationship with other RCDs.This article summarizes the two aspects in order to provide a new research direction for the treatment of ferroptosis-related diseases.

关 键 词：铁死亡 细胞死亡 铁 脂质过氧化作用 综述 

分 类 号：R329.25[医药卫生—人体解剖和组织胚胎学]