2019年南昌市首例新生儿B群流行性脑脊髓膜炎病例调查  

Investigation on the first case of group B cerebrospinal meningitis in neonates in Nanchang City,Jiangxi Province,China in 2019

作　　者：张艳霞[1] 许波[1] 文海蓉[1] 彭时辉[1] ZHANG Yan-xia;XU Bo;WEN Hai-rong;PENG Shi-hui(The Collaboration Unit for Field Epidemiology of State Key Laboratory for Infectious Disease Prevention and Control,Nanchang Center for Disease Control and Prevention,Nanchang 330038,Jiangxi Province,China)

机构地区：[1]南昌市疾病预防控制中心,传染病预防控制国家重点实验室研究基地,江西南昌330038

出　　处：《中国生物制品学杂志》2020年第9期1029-1030,1036,共3页Chinese Journal of Biologicals

基　　金：江西省卫生计生委科技计划(20171786)。

摘　　要：目的调查2019年南昌市首例新生儿B群流行性脑脊髓膜炎(简称流脑)病例的发病特点及流行病学特征。方法查阅患儿的病历资料,开展流行病学调查,对监护人及家属进行访视,采集患儿血样本、脑脊液样本及密切接触者咽拭子样本进行病原培养。结果患儿为出生24 d的女婴,出现发热,稍吐沫伴反应差、双眼凝视、口唇微绀等症状。从患儿血液样本中检出1株B群脑膜炎双球菌(Neisseria meningitidis,Nm),患儿脑脊液样本及患儿的密切接触者咽拭子样本中未检出Nm。结论应加强流脑防控,及时掌握南昌市流脑流行菌群的变化。Objective To investigate the pathogenic and epidemiological characteristics of the first case of group B cerebrospinal meningitis in neonates in Nanchang City,Jiangxi Province,China in 2019.Methods The medical record of the case was consulted,while an epidemiological investigation was carried out,and the guardians and family members were visited.Blood samples and cerebrospinal fluid samples of patient as well as the pharyngeal swabs of close contacts were collected for pathogen culture.Results Fever,slightly frothing with poor reaction,gazing with both eyes and cyanosis of mouth and lips were observed in a female neonate at age of 24 days.The blood sample of the neonate was positive for group B Neisseria meningitii(Nm).No Nm was detected in the cerebrospinal fluid sample of patient or in the swab samples of close contacts.Conclusion The prevention and control of encephalitis in Nanchang should be strengthened in order to grasp the changes of epidemic bacteria of encephalitis in the city.

关 键 词：流行性脑脊髓膜炎 B群脑膜炎双球菌 流行病学 

分 类 号：R378.15[医药卫生—病原生物学] R392-33[医药卫生—基础医学]