细胞基质流行性感冒疫苗及其生产方式的研究进展  

Progress in research on cell-based influenza vaccine and its production procedure

作　　者：高宁 赵慧(综述)[2] 姜崴[1] 李长贵(审校)[2] GAO Ning;ZHAO Hui;JIANG Wei;LI Chang-gui(Changchun Institute of Biological Products,Changchun 130012,Jilin Province,China;不详)

机构地区：[1]长春生物制品研究所,吉林长春130012 [2]中国食品药品检定研究院呼吸道病毒疫苗室卫生部生物技术产品检定方法及其标准化重点实验室,北京102629

出　　处：《中国生物制品学杂志》2020年第9期1076-1080,共5页Chinese Journal of Biologicals

基　　金：北京市自然科学基金项目(7173277);中国食品药品检定研究院学科带头人培养基金(2015X7)。

摘　　要：流行性感冒病毒(简称流感病毒)引起的流行性感冒(简称流感)是世界最大的公共卫生挑战之一。WHO建议每年接种流感疫苗,这是预防流感的最有效方法。流感疫苗生产一般通过鸡胚生产,但无法在大流行时满足需求,现新型流感疫苗均在研究利用合成培养基,通过微载体及悬浮培养进行流感疫苗生产,可在短时间内生产出有效的疫苗,作为鸡胚流感疫苗的补充。本文就目前细胞基质流感疫苗及其生产方式的研究进展作一综述。Influenza virus is one of the largest public health challenges in the world.WHO recommends annual influenza vaccination as the most effective way to prevent influenza.Influenza vaccine is generally produced by chicken embryos,which cannot meet the market needs during a pandemic.The production of novel influenza vaccines by microcarrier and suspension cultures using synthetic media is in study.An effective vaccine may be developed within a short period and used as a supplement to chicken embryo-based influenza vaccine.This paper reviews the progress in research on cellbased influenza vaccine and its production procedure.

关 键 词：流感病毒 流感疫苗 微载体培养 悬浮培养 

分 类 号：R373.13[医药卫生—病原生物学]