通体结香技术产沉香醇提物增强免疫作用研究  

Study on enhancing immune function of agarwood alcohol extract produced via whole-tree agarwood-inducing technique of Aquilaria sinensis

作　　者：王灿红 彭德乾[3] 吴玉兰 余章昕 郭鹏 魏建和[1,2] WANG Can-hong;PENG De-qian;WU Yu-lan;YU Zhang-xin;GUO Peng;WEI Jian-he(Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine,Key Laboratory of State Administration of Traditional Chinese Medicine for Agarwood Sustainable Utilization,Hainan Branch Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Haikou 570311,China;National Engineering Laboratory for Breeding of Endangered Medicinal Materials,Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine,Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100193,China;School of Pharmacy,Hainan Medical College,Haihou,Hainan,571199,China)

机构地区：[1]中国医学科学院,北京协和医学院,药用植物研究所,海南分所海南省南药资源保护与开发重点实验室国家中医药管理局沉香可持续利用重点研究室,海南海口570311 [2]中国医学科学院,北京协和医学院,药用植物研究所,中草药物质基础与资源利用教育部重点实验室濒危药材繁育国家工程实验室,北京100193 [3]海南医学院药学院,海南海口571199

出　　处：《时珍国医国药》2020年第5期1073-1075,共3页Lishizhen Medicine and Materia Medica Research

基　　金：国家重点研发计划项目(2018YFC1706400);海南省自然科学基金(817290,217291);中国医学科学院医学与健康科技创新工程项目(2016-I2M-2-003)。

摘　　要：目的评价通体沉香醇提物对正常和免疫抑制小鼠的免疫增强作用。方法采用环磷酰胺腹腔注射制备小鼠免疫抑制模型,沉香醇提物灌胃给药,分别计算小鼠的足趾肿胀程度、胸腺和脾脏指数、淋巴细胞增殖转化能力、抗体生成数及血清溶血素水平等免疫学指标。结果沉香醇提物高剂量可显著升高正常和免疫抑制小鼠的足趾肿胀程度、胸腺和脾脏指数、淋巴细胞增殖刺激因子、抗体生成数及血清半数溶血值。结论沉香醇提物可增强小鼠的免疫功能。Objective To evaluate the immune-enhancing effect of agarwood alcohol extract produced via whole-tree agarwood-inducing technique(WTAAE) of Aquilaria sinensis on normal and immunosuppressed mice. Methods Immunosuppression model mice were made by intraperitoneal injection of cyclophosphamide. WTAAE continuous lavage. Calculate toes swelling degree, indexes of thymus and spleen in mice, the transforming ability of lymphocyte proliferation, antibody generation number and half hemolytic value(HC50) were measured. Results The high dose of WTAAE significantly increased the degree of toe swelling, thymus and spleen indexes, lymphocyte proliferation, antibody production and HC50 in normal and immunosuppressed mice.Conclusion The results suggest that WTAAE could enhance the immune function of mice.

关 键 词：通体沉香醇提物 环磷酰胺 免疫抑制 免疫增强 

分 类 号：R284.1[医药卫生—中药学]