miRNA与2型糖尿病关系的研究进展  

RESEARCH ADVANCES IN THE RELATIONSHIP BETWEEN MIRNAS AND TYPE 2 DIABETES

作　　者：张方华[1] 高珊[1] 王秀秀 杨颖[1] 王晔[2] 姚民秀[1] ZHANG Fanghua;GAO Shan;WANG Xiuxiu;YANG Ying;WANG Ye;YAO Minxiu(Department of Endocrinology,Qingdao Central Hospital,The Second Clinical Medical College of Qingdao University,Qingdao 266042,China)

机构地区：[1]青岛市中心医院(青岛大学第二临床医学院)内分泌科,山东青岛226042 [2]青岛市中心医院(青岛大学第二临床医学院)中心实验室,山东青岛226042

出　　处：《青岛大学学报（医学版）》2020年第5期619-623,共5页Journal of Qingdao University(Medical Sciences)

基　　金：国家自然科学基金资助项目(81670822)。

摘　　要：2型糖尿病的主要病因是由多种因素引起的胰岛素缺乏和胰岛素抵抗。microRNA(miRNA)是很多生理过程及病理生理过程的重要调节因子,在多个生物学过程中发挥关键作用,如细胞增殖、分化、凋亡和癌变等。有研究表明,miRNA通过作用于多个通路促进胰岛素分泌或调节胰岛素抵抗,异常miRNA表达可能是2型糖尿病的潜在发病机制。本文就目前所知与2型糖尿病发病机制有关的miRNA进行综述。Type 2 diabetes is primarily caused by insulin deficiency and insulin resistance resulting from composite factors such as gene,environment,and diet.MicroRNAs(miRNAs)are important regulators of numerous physiological and pathophysiological processes.They play critical roles in various biological processes,including cell proliferation,differentiation,apoptosis,and carcinogenesis.It has been recently revealed that miRNAs promote insulin secretion or regulate insulin resistance by acting on multiple pathways,and abnormal miRNAs expression plays a potentially pathological role in type 2 diabetes.This article is a review of the currently known miRNAs related to the pathogenesis of type 2 diabetes.

关 键 词：微RNAS 糖尿病 2型 胰岛素抗药性 综述 

分 类 号：R587.1[医药卫生—内分泌]