成牙本质细胞分化信号通路研究进展  

Research progress of odontoblast differentiation signaling pathway

作　　者：田子璐 刘艺萍 王珏 朱松[1] 孙宏晨[1] 倪世磊[1] TIAN Zilu;LIU Yiping;WANG Jue;ZHU Song;SUN Hongchen;NI Shilei(Department of Prosthodontics,Stomatological Hospital of Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学口腔医院修复科,吉林长春130021

出　　处：《口腔医学》2020年第9期847-850,共4页Stomatology

基　　金：吉林省科技发展计划项目(20200403110SF);吉林省财政厅科技项目(JSC22019378-21)。

摘　　要：成牙本质细胞由牙髓干细胞分化而来。大量实验表明,在牙髓干细胞向成牙本质细胞分化过程中多种生物因子可激活Smad、MAPK、Wnt、Notch信号通路继而影响成牙本质细胞分化。而成牙本质细胞分化是成牙本质细胞有序排列并形成正常牙本质的重要前提。该文就近年来对成牙本质细胞分化信号通路的研究进展进行阐述。Odontoblasts are differentiated from dental pulp stem cells.A large number of experiments have shown that many kinds of biological factors can activate Smad,MAPK,Wnt,Notch signal pathways to affect the differentiation of odontoblasts.The differentiation of odontoblasts is an important premise for the orderly arrangement odontoblasts and the formation of normal dentin.In this paper,the research progress of differentiation signaling pathway of odontoblasts in recent years was reviewed.

关 键 词：成牙本质细胞 SMAD MAPK WNT NOTCH 

分 类 号：R349.54[医药卫生—基础医学]