个人护理用品中甘草酸二钾含量的测定  

Determination of dipotassium glycyrrhizinate in personal care products

作　　者：陈燕 袁旻嘉 王艳玲 于丽丽 胡新成 CHEN Yan;YUAN Min-jia;WANG Yan-ling;YU Li-li;HU Xin-cheng(Shanghai Chicmax Cosmetic Co.,Ltd.,Shanghai 200333,China)

机构地区：[1]上海上美化妆品有限公司,上海200333

出　　处：《日用化学品科学》2020年第10期26-28,40,共4页Detergent & Cosmetics

摘　　要：建立高效液相色谱法检测不同基质类型的个人护理用品(洗发露、沐浴露、护发素、洁面乳)中甘草酸二钾含量的测定方法。采用ZORBAX SB-C18(4.6 mm×250 mm,5μm)色谱柱,以0.01 mol/L磷酸溶液-乙腈为流动相(体积比63∶37)等度洗脱。样品经甲醇超声提取,采用二极管阵列检测器检测。由实验结果可知,甘草酸二钾质量浓度在1~200μg/mL时线性关系良好(R2=0.9997),洗发露、沐浴露、护发素和洁面乳中甘草酸二钾测定的加标平均回收率分别为92.92%~101.69%。该方法具有较高的准确度和精密度,可快速对个人护理用品中甘草酸二钾定性定量分析。A method for the determination of dipotassium glycyrrhizinate in various personal care products(shampoo,shower gel,hair conditioner and facial cleanser)with high performance liquid chromatography was established.ZORBAX SB-C18 column(4.6 mm×250 mm,5μm)was used.The 0.01 mol/L phosphoric acid solution-acetonitrile(63∶37)was used as mobile phase in the isocratic elution.The sample was treated by ultrasonic extraction with methanol and detected by diode array detector.The experimental results showed that,dipotassium glycyrrhizinate showed a good linear relationship in the concentration range of 1~200μg/mL(R2=0.9997).The average recovery rates of dipotassium glycyrrhizinate in the shampoo,shower gel,hair conditioner and facial cleanser were 92.92%~101.69%.The method had good precision and accuracy and could be used for the rapid qualitative and quantitative analysis of dipotassium glycyrrhizinate in personal care products.

关 键 词：高效液相色谱法 个人护理用品 甘草酸二钾 

分 类 号：TQ658[化学工程—精细化工]