静脉滴注缩宫素计划分娩对孕足月胎膜早破孕妇血清IL-6和细胞粘附因子-1水平的影响  

Effect of intravenous drip of oxytocin in planned delivery on serum IL-6 and cell adhesion molecule-1 of pregnant women with term premature rupture of membrances

作　　者：于艳丽 郑皆红 YU Yan-li;ZHENG Jie-Hong(Department of Gynecology and Obtetric.the First Hospitad 0/Ninghai County,Ningbo,Zhejiang 315600,Chinn)

机构地区：[1]宁海县第一医院妇产科,浙江宁波315600 [2]宁波市江北区妇幼保健院,浙江宁波315020

出　　处：《中国妇幼保健》2020年第19期3594-3596,共3页Maternal and Child Health Care of China

摘　　要：目的探讨静脉滴注缩宫素计划分娩对孕足月胎膜早破孕妇血清白细胞介素-6 (IL-6)、细胞粘附因子-1 (CAM-1)的影响。方法选取2017年6月-2019年6月于该院就诊的86例孕足月胎膜早破孕妇为研究对象,按随机数字表法分为观察组和对照组,各43例。对照组以林格液持续滴注,并在孕妇宫口扩大至3 cm后停止使用缩宫素,而观察组则在孕妇感觉宫缩到分娩完成之后持续使用缩宫素,对比两组分娩结局、血清IL-6、CAM-1变化以及产后情况。结果观察组总产程、用药至分娩完成时间短于对照组且产褥感染发生率少于对照组(P<0.05);两组产后24 h出血量对比,差异无统计学意义(P>0.05);观察组自然分娩率高于对照组(P<0.05);观察组宫内窘迫发生率低于对照组(P<0.05);两组新生儿宫内感染发生率对比,差异无统计学意义(P>0.05);观察组新生儿Apgar评分高于对照组(P<0.05);两组产前血清IL-6、CAM-1指标对比,差异无统计学意义(P>0.05);两组产后血清IL-6、CAM-1均有所降低且观察组降低程度优于对照组(P<0.05)。结论在孕足月胎膜早破中以静脉滴注缩宫素进行计划分娩可以降低孕产妇及新生儿不良事件发生,提高自然分娩率,改善炎性反应,值得临床广泛应用。Objective To explore the effect of intravenous drip of oxytocin in planned delivery on serum interleukin-6(IL-6)and cell adhesion molecule-1(CAM-1)of pregnant women with term premature rupture of membrances.Methods Eighty-six pregnant women with term premature rupture of membrances diagnosed and treated in the First Hospital of Ninghai County from June 2017 to June 2019 were selected and divided into observation group and control group according to random number table,43 women in each group.The women in control group were treated by continuous intravenous drip of Ringer solution,oxytocin was discontinued when uterine orifice was dilated to3 cm;the women in observation group were treated by oxytocin continuously till end of delivery.The delivery outcomes,serum IL-6 and CAM-1 levels,postpartum situations in the two groups were compared.Results The time of total stage of labor,the time from usage of medication to end of delivery in observation group was statistically significantly less than that in control group(P<0.05);there was no statistically significant difference in the amount of bleeding within 24 hours after delivery between the two groups(P>0.05);the rate of spontaneous labor in observation group was statistically significantly higher than that in control group(P<0.05);the incidence rate of intrauterine distress in observation group was statistically significantly lower than that in control group(P<0.05);there was no statistically significant difference in the incidence rate of intrauterine infection between the two groups(P>0.05);neonatal Apgar score in observation group was statistically significantly higher than that in control group(P<0.05);there was no statistically significant difference in the levels of serum IL-6 and CAM-1 between the two groups(P>0.05);after delivery,serum IL-6 and CAM-1 levels in the two groups decreased,especially in observation group(P<0.05).Conclusion Intravenous drip of oxytocin in planned delivery among pregnant women with term premature rupture of membrances can reduce mater

关 键 词：静脉滴注缩宫素 计划分娩 孕足月 胎膜早破 血清白细胞介素-6 细胞粘附因子-1 

分 类 号：R719.3[医药卫生—妇产科学]