多索茶碱联合厄多司坦治疗慢性阻塞性肺疾病急性加重期效果及对肺功能和抗氧化能力的影响  

Efficacy of Doxofylline Combined with Erdosteine in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease and Its Effects on Lung Function and Antioxidant Capacity Indexes of Patients

作　　者：余彪 向伟 YU Biao;XIANG Wei(Department of Emergency,Meishan People's HospitalWest China Hospital of Sichuan University,Meishan,Sichuan 620010,China)

机构地区：[1]四川大学华西医院眉山医院眉山市人民医院急诊科,四川眉山620010

出　　处：《解放军医药杂志》2020年第10期49-53,共5页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：四川省卫生厅项目(150135)。

摘　　要：目的探讨多索茶碱联合厄多司坦治疗慢性阻塞性肺疾病急性加重期(AECOPD)疗效及对患者肺功能和抗氧化能力的影响。方法回顾性分析2017年6月—2019年6月收治的AECOPD 106例,按治疗方法分为研究组和对照组,每组53例。对照组给予多索茶碱治疗,研究组在对照组基础上给予厄多司坦治疗。比较2组治疗8周后临床疗效,治疗前、治疗8周后肺功能指标、呼吸困难程度、抗氧化能力指标、生活质量改善情况,并记录治疗8周期间药物不良反应发生情况。结果治疗8周后,研究组总有效率高于对照组(P<0.05)。治疗8周后,研究组第一秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC、超氧化物歧化酶、谷胱甘肽、总抗氧化能力较治疗前升高,而呼吸困难程度、欧洲五维生活质量量表、丙二醛水平下降,且研究组上述指标优于对照组(P<0.05)。治疗8周期间,研究组不良反应发生率低于对照组(P<0.05)。结论对于AECOPD患者,应用多索茶碱联合厄多司坦治疗效果显著,可明显改善肺功能,提升抗氧化能力及生活质量,且安全性较高。Objective To explore the efficacy of Doxofylline combined with Erdosteine in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)and its effects on lung function and antioxidant capacity indexes of patients.Methods A total of 106 AECOPD patients admitted from June 2017 to June 2019 were retrospectively analyzed.According to the treatment methods,they were divided into research group and control group,with 53 patients in each group.The control group was treated with Doxofylline and the research group was treated with Erdosteine on the basis of the control group.The clinical efficacy at 8 weeks after treatment,and lung function indicators,dyspnea degree,antioxidant capacity indexes and quality of life before treatment and at 8 weeks after treatment was compared between the two groups,and the occurrence of adverse drug reactions during 8 weeks of treatment was recorded.Results After 8 weeks of treatment,the total effective rate in research group was significantly higher than that in control group(P<0.05).After 8 weeks of treatment,the forced expiratory volume in 1 second(FEV1),forced vital capacity(FVC),FEV1/FVC,superoxide dismutase(SOD),glutathione(GSH)and total antioxidant capacity(TAC)in research group were significantly increased compared with those before treatment,while dyspnea degree,European quality of life 5-dimensions(EQ-5D)score and malondialdehyde(MDA)level were significantly reduced.The indexes in research group during the same period were significantly better than those in control group(P<0.05).During 8 weeks of treatment,the adverse reaction rate in research group was significantly lower than that in control group(P<0.05).Conclusion For patients with AECOPD,Doxofylline combined with Erdosteine has a significant treatment effect,which can significantly improve lung function,and enhance antioxidant capacity and quality of life with good safety.

关 键 词：肺疾病 慢性阻塞性 急性加重期 多索茶碱 厄多司坦 第一秒用力呼气容积 用力肺活量 超氧化物歧化酶 呼吸困难 生活质量 

分 类 号：R563.9[医药卫生—呼吸系统]