A组链球菌粘附和定植机制的研究进展  

Advances in the mechanisms of Group A Streptococcal adherence and colonization

作　　者：蔡明辉[1] 宋英莉[1] 陈竑量 朱辉[1] Cai Minghui;Song Yingli;Chen Hongliang;Zhu Hui(Department of Physiology,Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学生理学教研室,150081

出　　处：《国际免疫学杂志》2020年第4期413-418,共6页International Journal of Immunology

基　　金：国家自然科学基金项目(81571957);黑龙江省博士后基金(LBH-Z17154);黑龙江省大学生创新创业训练计划项目(201910226031)。

摘　　要：A组链球菌(Group A Streptococcus,GAS)是链球菌中致病性最强的细菌之一,可引起咽炎、脓疱病、猩红热、败血症等各种感染性疾病。GAS致病的最初阶段和最重要的阶段是在宿主特定的组织或器官上的粘附和定植,因此了解GAS粘附和定植机制对于GAS致病性的研究具有重要意义。以下将对GAS粘附和定植机制的研究进展作一简要综述。Group A Streptococcus is the most pathogenic bacteria of streptococcus,which can cause pharyngitis,impetigo,scarlet fever,sepsis and other infectious diseases.However,no matter what kind of infection,the initial stage of pathogenesis is the adherence and colonization on specific tissues or organs of the host.It is of great significance to investigate the mechanisms of GAS adherence and colonization for understanding the pathogenesis of GAS.This paper will give a brief review on the research progress of GAS adherence and colonization mechanisms.

关 键 词：A组链球菌 粘附 粘附素 定植 

分 类 号：R378.12[医药卫生—病原生物学]