芪枝渴痹通胶囊联合针刺治疗气虚血瘀证糖尿病周围神经病变临床研究  

Clinical Study on Qizhi Kebitong Capsules Combined with Acupuncture for Diabetic Peripheral Neuropathy with Qi Deficiency and Blood Stasis Syndrome

作　　者：王国强[1] 米佳[1] 于淼[1] 赵芸芸[2] 王秀阁[1] WANG Guoqiang;MI Jia;YU Miao;ZHAO Yunyun;WANG Xiuge

机构地区：[1]长春中医药大学附属医院,吉林长春130021 [2]长春中医药大学,吉林长春130000

出　　处：《新中医》2020年第19期75-78,共4页New Chinese Medicine

基　　金：吉林省中医药科技项目(2018050);吉林省卫生与健康技术创新项目(2018J103)。

摘　　要：目的:观察芪枝渴痹通胶囊联合针刺治疗气虚血瘀证糖尿病周围神经病变的临床疗效及其对神经传导速度的影响。方法:将120例糖尿病周围神经病变患者随机分为治疗组和对照组,各60例。2组均接受基础治疗,治疗组给予芪枝渴痹通胶囊联合针刺治疗,对照组给予甲钴胺片治疗。观察2组中医临床症状、多伦多(Toronto)临床评分及神经传导速度改善情况。结果:总有效率治疗组为81.67%,对照组为61.67%,2组比较,差异有统计学意义(P<0.01)。治疗后,2组临床症状积分、Toronto临床评分均较治疗前明显下降(P<0.01),且治疗组两项评分均明显低于对照组(P<0.01)。治疗后,2组正中神经、尺神经、腓总神经、胫前神经的运动传导速度(MNCV)、感觉传导速度(SNCV)均较治疗前升高(P<0.01),且治疗组各项指标改善较对照组更显著(P<0.01)。结论:芪枝渴痹通胶囊联合针刺治疗气虚血瘀证糖尿病周围神经病变,可有效改善神经传导速度,提高临床疗效。Objective:To observe the clinical effect of Qizhi Kebitong capsules combined with acupuncture for diabetic peripheral neuropathy with qi deficiency and blood stasis syndrome and its effect on nerve conduction velocity. Methods:A total of 120 cases of patients with diabetic peripheral neuropathy were randomly divided into the treatment group and the control group,60 cases in each group. Both groups were given basic treatment;the treatment group was additionally given Qizhi Kebitong capsules combined with acupuncture;the control group was additionally given mecobalamin tablets. The improvement of clinical symptoms of Chinese medicine,Toronto clinical scores and nerve conduction velocity were observed in the two groups. Results:The total effective rate was 81.67% in the treatment group and 61.67% in the control group,the difference being significant(P<0.01). After treatment,the clinical symptom scores,Toronto clinical scores in the two groups were significantly decreased when compared with those before treatment(P<0.01), and the two scores in the treatment group were significantly lower than those in the control group(P<0.01). After treatment,the motor nerve conduction velocity(MNCV) and sensory never conduction velocity(SNCV) of median nerve,ulnar nerve,common peroneal nerve and posterior tibial nerve in the two groups were increased when compared with those before treatment(P<0.01),and all indexes in the treatment group was more significant than that in the control group(P<0.01). Conclusion: The therapy of Qizhi Kebitong capsules combined with acupuncture for diabetic peripheral neuropathy with qi deficiency and blood stasis syndrome can effectively improve nerve conduction velocity and clinical effect.

关 键 词：糖尿病周围神经病变 益气活血通络法 芪枝渴痹通胶囊 针刺 

分 类 号：R587.2[医药卫生—内分泌] R246[医药卫生—内科学]