阿加曲班联合丁苯酞治疗急性脑梗死临床评价  

Agartroban Combined with Butylphthalide in Treating Acute Cerebral Infarction

作　　者：牛亚妹 刘丽 NIU Yamei;LIU Li(Luquan District Hospital of Traditional Chinese Medicine,Shijiazhuang,Hebei,China 050200)

机构地区：[1]河北省石家庄市鹿泉区中医院,河北石家庄050200

出　　处：《中国药业》2020年第20期86-88,共3页China Pharmaceuticals

基　　金：河北省医学科学研究重点课题[20171042]。

摘　　要：目的探讨阿加曲班联合丁苯酞治疗急性脑梗死的临床疗效及对患者微栓子、炎性因子与颈动脉硬化斑块的影响。方法选取医院2017年4月至2019年4月收治的急性脑梗死患者96例,随机分为观察组和对照组,各48例。两组患者均予抗血小板、改善微循环、控制血压、补充电解质平衡等基础治疗,并给予依达拉奉注射液、阿托伐他汀钙片及丁苯酞氯化钠注射液治疗,观察组患者加用阿加曲班注射液,均治疗2周。结果观察组总有效率为89.58%,显著高于对照组的72.92%(P<0.05);治疗后,与对照组比较,观察组患者美国国立卫生研究院卒中量表(NIHSS)评分及肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、白细胞介素6(IL-6)水平均显著降低,简易精神状态评价量表(MMSE)评分和日常生活能力(ADL)评分均显著升高(P<0.05),微栓子个数显著减少(P<0.05);斑块体积显著缩小(P<0.05);观察组和对照组不良反应发生率相当(14.58%比8.33%,P>0.05)。结论阿加曲班联合丁苯酞治疗急性脑梗死,能改善患者的神经功能、认知功能和生活质量,降低炎性因子水平,并能减少微栓子个数,缩小颈动脉硬化斑块体积。Objective To investigate the effects of agartroban combined with butylphthalide on microemboli,inflammatory factors and carotid atherosclerosis plaque in patients with acute cerebral infarction.Methods A total of 96 patients with acute cerebral infarction admitted to the hospital from April 2017 to April 2019 were selected and randomly divided into the observation group and control group,48 cases in each group.Both groups were given basic treatments such as anti-platelet aggregation,improvement of microcirculation,control of blood pressure,and supplement of electrolyte balance,and were given edaravone injection,atorvastatin calcium tablets and butylphthalide sodium chloride injection.The observation group was added with argatroban injection.All patients were treated for 2 weeks.Results The total effective rate of the observation group was 89.58%,which was significantly higher than 72.92%in the control group(P<0.05);after treatment,the National Institutes of Health Stroke Scale(NIHSS)score,the levels of tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP),interleukin 6(IL-6)in the observation group were significantly lower than those of the control group,and the scores of the Mini Mental State Evaluation Scale(MMSE)and the ability of daily living(ADL)were significantly higher than those of the control group(P<0.05);the number of microemboli was significantly less than that of the control group(P<0.05);the plaque volume was significantly smaller than that of the control group(P<0.05);the incidence of adverse reactions in the observation group and the control group was equal(14.58%vs.8.33%,P>0.05).Conclusion Argatroban combined with butylphthalide in the treatment of acute cerebral infarction can improve the patient’s neurological function,cognitive function and quality of life,reduce the level of inflammatory factors,reduce the number of microemboli,and reduce the volume of carotid atherosclerotic plaques.

关 键 词：急性脑梗死 阿加曲班 丁苯酞 微栓子 炎性因子 颈动脉硬化斑块 疗效 

分 类 号：R969.4[医药卫生—药理学] R973.2[医药卫生—药学]