醒脑静注射液联合甲氯芬酯治疗急性酒精中毒效果分析  

Effect of Xingnaojing injection combined with meclofenoxate on acute alcoholism

作　　者：谢静[1] 徐丽霞[2] 吕爱红[3] XIE Jing;XU Li-xia;LV Ai-hong(Department of Emergency,Second Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450000,China;不详)

机构地区：[1]郑州大学第二附属医院急诊科,河南郑州450000 [2]郑州市第二人民医院心血管内科 [3]郑州市第一人民医院神经内科

出　　处：《青岛医药卫生》2020年第5期338-340,共3页Qingdao Medical Journal

摘　　要：目的研究醒脑静注射液联合注射用盐酸甲氯芬酯治疗急性酒精中毒的效果。方法选取2018年1月至2019年1月本院收治的急性酒精中毒的患者94例为研究对象,随机分为对照组和观察组各47例。对照组予以盐酸甲氯芬酯治疗,观察组在对照组治疗基础上予以醒脑静治疗。观察两组患者治疗有效率,苏醒时间及中毒症状消失时间、氧代谢指标、血清氧化应激指标,苏醒后患者不适症状发生情况。结果观察组治疗总有效率明显高于对照组(P<0.05);观察组苏醒时间及中毒症状消失时间均短于对照组(P<0.05);治疗后观察组血氧饱和度及血氧含量均高于对照组(P<0.05);治疗后观察组总氧化能力(TAC)、过氧化氢酶(CAT)均升高,观察组高于对照组(P<0.05);治疗后观察组脂质过氧化物(LPO)低于对照组(P<0.05);观察组苏醒后不适症状发生率明显低于对照组(P<0.05)。结论醒脑静注射液联合注射用盐酸甲氯芬酯治疗急性酒精中毒效果确切,能够促进患者苏醒和改善症状,调节氧代谢及氧化应激指标,减少苏醒后不适症状的发生。Objective To study the effect of Xingnaojing injection combined with meclofenoxate hydrochloride on acute alcoholism.Methods A total of 94 patients with acute alcoholism treated in our hospital from January 2018 to January 2019 were selected as the research subjects.They were divided into the control group and the observation group randomly,with 47 cases in each group.The control group was treated with meclofenoxate hydrochloride,and the observation group was treated with Xingnaojing based on the treatment of the control group.The treatment efficiency,the time to wake up and the disappearance of symptoms of poisoning,indicators of oxygen metabolism,serum oxidative stress indicators,patients with symptoms of discomfort after awakening were compared between the two groups.Results The total effective rate in the observation group was significantly higher than that in the control group(P<0.05).The wake-up time and the disappearance of poisoning symptoms in the observation group were shorter than those in the control group(P<0.05).The oxyhemoglobin saturation and oxygen content of blood in the observation group after treatment were higher than those of the control group(P<0.05).The TAC and CAT were increased in the observation group after treatment,and the observation group was higher than the control group(P<0.05).The LPO in the observation group was lower than the control group after treatment(P<0.05).The incidence of discomfort after treatment in the observation group was significantly lower than that in the control group(P<0.05).Conclusion Xingnaojing injection combined with meclofenoxate hydrochloride for acute a lcoholism is effective,it can promote patients to wake up and improve symptoms,regulate poplar metabolism and oxidative stress indicators,and reduce the occurrence of discomfort after wakening.

关 键 词：醒脑静注射液 盐酸甲氯芬酯 血氧饱和度 血清氧化应激指标 

分 类 号：R595.6[医药卫生—内科学]