脉血康胶囊联合阿司匹林治疗非瓣膜性心房纤颤的临床效果  

Clinical efficacy of Maixuekang capsule combined with aspirin in treating nonvalvular atrial fibrillation

作　　者：李丹丹 沈荣兴 花婷婷 徐晓明[2] LI Dandan;SHEN Rongxing;HUA Tingting(Department of Cardiology,Second People’s Hospital of Tongxiang,Tongxiang 314511,CHINA)

机构地区：[1]桐乡市第二人民医院心血管内科,浙江314511 [2]浙江省中医院心血管内科

出　　处：《江苏医药》2020年第9期885-888,共4页Jiangsu Medical Journal

基　　金：浙江省自然科学基金(LQ17H290003)。

摘　　要：目的探讨脉血康胶囊联合阿司匹林对非瓣膜性心房纤颤患者的治疗效果。方法将120例非瓣膜性心房纤颤患者随机均分为阿司匹林联合脉血康胶囊治疗组(A组)和单用阿司匹林治疗组(B组)。比较两组一般临床资料、凝血功能及血液流变学变化、治疗总有效率、不良反应及终点事件发生情况。结果与B组相比,A组治疗后纤维蛋白原、红细胞沉降率和高切全血黏度降低(P<0.05),活化部分凝血酶时间增加(P<0.05)。A组治疗后总有效率高于B组(95.00%vs.81.67%)(P<0.05)。两组治疗后不良反应发生率差异无统计学意义(5.00%vs.8.33%)(P>0.05)。A组终点事件发生率低于B组(3.33%vs.15.00%)(P<0.05)。结论阿司匹林和脉血康胶囊联合使用较阿司匹林单用更能有效改善非瓣膜性心房纤颤患者血液流变学和凝血状况,降低终点事件发生率。Objective To investigate the clinical efficacy of Maixuekang capsule combined with aspirin in the treatment of patients with nonvalvular atrial fibrillation.Methods A total of 120 patients with nonvalvular atrial fibrillation was equally randomized into two groups of A and B.The patients in group A were treated with combined oral administration of Maixuekang capsule and aspirin and those in group B were.administrated aspirin alone.The changes of coagulation function and hemorheology,overall effective rate,adverse reactions and endpoint events were compared between the two groups.Results Compared with group B,the fibrinogen,erythrocyte sedimentation rate and high blood viscosity were decreased(P<0.05),while the activated partial thromboplastin time was increased in group A(P<0.05).The overall effectiveness rate after treatment in group A was higher than that in group B(95.00%vs.81.67%)(P<0.05).There was no statistical difference in the incidence of adverse reactions between groups of A and B(5.00%vs.8.33%)(P>0.05).Moreover,the incidence of endpoint events in group A was lower than that in group B(3.33%vs.15.00%)(P<0.05).Conclusion Combined use of Maixuekang capsule and aspirin is better than aspirin alone in improving the hemorheology and coagulation function,and decreasing the incidence of endpoint events in the patients with nonvalvular atrial fibrillation.

关 键 词：非瓣膜性心房纤颤 脉血康胶囊 阿司匹林 

分 类 号：R541[医药卫生—心血管疾病]