空气污染对高血压影响及其机制的研究进展  

Research progress on effect of air pollution on hypertension and its mechanisms

作　　者：杨荣军 林敏[1] 舒承福 王庆海 YANG Rong-jun;LIN Min;SHU Cheng-fu;WANG Qing-hai(Department of Cardiology,The Second People's Hospital of China Three Gorges University,Yichang,Hubei 443000,China)

机构地区：[1]三峡大学第二人民医院心内科,湖北宜昌443000

出　　处：《环境与职业医学》2020年第9期922-928,935,共8页Journal of Environmental and Occupational Medicine

摘　　要：空气污染与高血压的发生发展密切相关。本综述阐述了不同暴露时间及易感人群的空气污染与高血压的流行病学研究;论述了空气污染可能促发或诱导高血压发生发展的生物学机制,包括自主神经系统失衡,氧化应激和免疫炎症反应以及内皮功能障碍等多种机制相互作用;分析表明减轻空气污染可降低心血管毒性效应,提出我国今后需开展大规模的相关研究,为进一步加强高血压早期防控提供一定的依据。Air pollution is closely related to the occurrence and progression of hypertension.This article expounded the epidemiological relationships between hypertension and air pollution in different exposure time and susceptible populations.It also discussed the biological mechanisms of air pollution in promoting or inducing the occurrence or progression of hypertension,including the imbalance of autonomic nervous system,oxidative stress,immune inflammation,and endothelial dysfunction.The analysis results showed that alleviating air pollution can reduce related cardiovascular toxic effects,and large-scale research on this pair association is required in China in the future to provide a basis for further strengthening the early prevention and control of hypertension.

关 键 词：空气污染 高血压 平均动脉压 脉搏压 生物学机制 心血管毒性 

分 类 号：R12[医药卫生—环境卫生学]