益肾健骨丸内服联合强筋益肾健骨膏外敷治疗膝骨关节炎肝肾亏虚证临床研究  

Clinical Study on Yishen Jiangu Pills Combined with Qiangjin Yishen Jiangu Plaster for Treatment of Deficiency of Liver and Kidney of Knee Osteoarthritis

作　　者：柴喜平[1] 李盛华[1] 柳海平[1] 尤从新[1] 赵宁[1] 张锐[1] 李爱强[1,2] CHAI Xiping;LI Shenghua;LIU Haiping;YOU Congxin;ZHAO Ning;ZHANG Rui;LI Aiqiang(Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China;Gansu Academy of Traditional Chinese Medicine,Lanzhou 730050,China)

机构地区：[1]甘肃省中医院,甘肃兰州730050 [2]甘肃省中医药研究院,甘肃兰州730050

出　　处：《中国中医药信息杂志》2020年第10期37-41,共5页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金地区基金(81560782/H2710);甘肃陇中正骨学术流派传承工作室建设项目(LP0128061);中医药行业科研专项(201507001-06)。

摘　　要：目的评价益肾健骨丸内服联合强筋益肾健骨膏外敷治疗膝骨关节炎(KOA)肝肾亏虚证临床疗效。方法采用随机数字表法将116例KOA患者分为对照组和观察组各58例。对照组予常规治疗(患膝关节注射玻璃酸钠注射液+口服对乙酰氨基酚片),观察组予益肾健骨丸内服+强筋益肾健骨膏外敷,均连续治疗12周。观察2组治疗前后疼痛视觉模拟量表(VAS)评分、西安大略和麦克马斯特大学骨关节炎指数(WOMAC)评分、膝骨关节炎严重性指数(ISOA)、中医症状积分、焦虑自评量表(SAS)评分、抑郁自评量表(SDS)评分,比较2组临床疗效,监测2组不良反应。结果对照组脱落8例。与本组治疗前比较,2组活动和静息时VAS评分降低,WOMAC总分及疼痛、僵硬、关节功能评分明显降低,ISOA总分及症状体征评分、最大步行距离评分、日常活动评分明显降低,中医症状积分、SAS评分、SDS评分明显降低(P<0.05);2组治疗后比较,观察组上述各项评分均明显低于对照组(P<0.05)。观察组总有效率为91.38%(53/58),对照组为78.00%(39/50),观察组明显优于对照组(P<0.05)。2组均未见明显不良反应。结论益肾健骨丸内服联合强筋益肾健骨膏外敷可显著减轻KOA患者临床症状,改善关节功能,提高生活质量。Objective To study the clinical efficacy of Yishen Jiangu Pills(YJP)combined with Qiangjin Yishen Jiangu Plaster(QYJP)for deficiency of liver and kidney caused by knee osteoarthritis(KOA).Methods Totally 116 KOA patients were randomly divided into two groups according to random number table method:control group(58 cases)and observation group(58 cases).Patients in control group got sodium hyaluronate injection and paracetamol tablets.Patients in observation group got YJP and QYJP.The course of treatment was 12 weeks.The visual analogue scale(VAS)score,Western Ontario and Mc Master Universities osteoarthritis index(WOMAC)score,index of severity for osteoarthritis(ISOA),TCM symptom scores,self-rating anxiety scale(SAS)score,self-rating depression scale(SDS)score before and after treatment were observed.The clinical efficacy of the two groups was compared,and adverse reactions were monitored.Results There were 8 patients in the control group who did not complete treatment.Compared with before treatment,scores of VAS during activity and rest decreased,WOMAC total score and pain,stiffness,joint function score,ISOA total score and symptom signs score,maximum walking distance score,daily activity score,TCM symptom score,SAS score,and SDS score were significantly reduced(P<0.05);after treatment,the scores of the observation group were significantly lower than those of the control group(P<0.05).The total effective rate in the observation group was 91.38%(53/58)and that in the control group was 78.00%(39/50).The observation group was significantly better than the control group(P<0.05).There was no significant adverse reactions in the 2 groups.Conclusion YJP combined with QYJP can relieve clinical symptoms of patients with KOA,ameliorate joint function to improve patients’quality of life.

关 键 词：膝骨关节炎 肝肾亏虚证 益肾健骨丸 强筋益肾健骨膏 关节功能 临床研究 

分 类 号：R274.94[医药卫生—中西医结合]