槐耳颗粒辅助西医疗法治疗原发性肝癌疗效及安全性Meta分析  

Meta-analysis on Efficacy and Safety of Huaier Granules Assisted with Western Medicine in Treatment of Primary Hepatocellular Carcinoma

作　　者：李丽[1] 吴驻林 梁彩君 韩志毅[2] 彭立生[2] LI Li;WU Zhulin;LIANG Caijun;HAN Zhiyi;PENG Lisheng(The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine,Shenzhen 518033,China;Shenzhen Traditional Chinese Medicine Hospital,Shenzhen 518033,China)

机构地区：[1]广州中医药大学第四临床医学院,广东深圳518033 [2]深圳市中医院,广东深圳518033

出　　处：《中国中医药信息杂志》2020年第10期103-109,共7页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：深圳市科技计划(JCYJ20180302173542393)。

摘　　要：目的系统评价槐耳颗粒辅助西医疗法治疗原发性肝癌的疗效和安全性。方法计算机检索CochraneLibrary、PubMed、Embase、中国知识资源总库(CNKI)、中文科技期刊数据库(维普网)、中国生物医学文献数据库(CBM)、中国学术期刊数据库(万方数据),并行手工检索。检索范围为建库至2019年6月。收集槐耳颗粒辅助西医疗法治疗原发性肝癌(试验组)对比常规西医治疗(对照组)的临床随机对照试验(RCT),提取资料并运用Cochrane协作网偏倚风险评估工具进行质量评价,采用RevMan5.3进行Meta分析。结果共纳入13个RCT,涉及患者919例。Meta分析结果显示,试验组近期有效率(RR=1.40,95%CI[1.22,1.59],P<0.00001)、生活质量(RR=1.24,95%CI[1.07,1.44],P=0.005)、1年生存率(RR=1.52,95%CI[1.21,1.92],P=0.0004)、甲胎蛋白变化有效率(RR=1.18,95%CI[1.04,1.33],P=0.008)、降低不良反应(骨髓抑制、肝功能损害)均优于对照组,差异有统计学意义(P<0.05)。试验组外周血CD4^+T细胞(MD=9.79,95%CI[7.75,11.82],P<0.00001)水平明显高于对照组,差异有统计学意义(P<0.05)。2组胃肠道反应(RR=0.68,95%CI[0.39,1.19],P=0.18)及外周血CD8+T细胞水平(MD=-1.66,95%CI[-9.51,6.20],P=0.68)比较差异无统计学意义。结论槐耳颗粒辅助西医疗法治疗原发性肝癌疗效和安全性优于对照组,但需更多高质量RCT进行验证。Objective To evaluate the efficacy and safety of Huaier Granules assisted with Western medicine in the treatment of primary hepatocellular carcinoma(PHC).Methods Cochrane Library,PubMed,Embase,CNKI,VIP,CBM,and Wanfang database and relevant journals were searched for randomized controlled trials(RCTs)about Huaier Granules assisted with Western medicine for PHC(test group)versus routine Western medicine treatment of PHC(control group)from establishment to June 2019.All included researches were assessed using the Cochrane Collaboration Risk Bias Evaluation Tool and meta-analysis was conducted using RevMan5.3.Results Totally 13 RCTs were included,involving 919 patients.Results of meta-analysis showed that treatment group could improve the efficiency of treatment(RR=1.40,95%CI[1.22,1.59],P<0.00001),the quality of life(RR=1.24,95%CI[1.07,1.44],P=0.005),1-year survival rate(RR=1.52,95%CI[1.21,1.92],P=0.0004),and Alpha-fetoprotein change efficiency(RR=1.18,95%CI[1.04,1.33],P=0.008),and side effects such as bone marrow suppression and liver function damage lower than that of the control group,with statistical significance(P<0.05).Peripheral blood CD4^+T cell levels in treatment group showed higher than that in the control group(MD=9.79,95%CI[7.75,11.82],P<0.00001).Gastrointestinal response in two groups(RR=0.68,95%CI[0.39,1.19],P=0.18)and peripheral blood CD8+T cell levels(MD=-1.66,95%CI[-9.51,6.20],P=0.68)showed no statistically significant difference.Conclusion Huaier Granules assisted with Western medicine show better efficacy and safety in the treatment of PHC than the control group;however,higher quality RCTs are needed to verify.

关 键 词：槐耳颗粒 原发性肝癌 疗效 安全性 META分析 

分 类 号：R2-05[医药卫生—中医学] R273.57