氰霜唑及其主要代谢物CCIM在番茄和葡萄上的残留行为及膳食暴露风险评估  

Residues behavior and dietary exposure risk assessment of cyazofamid and its main metabolite CCIM in tomato and grape

作　　者：杨庆喜 纪明山[1] 谷祖敏[1] YANG Qingxi;JI Mingshan;GU Zumin(College of Plant Protection,Shenyang Agricultural University,Shenyang 110866,China)

机构地区：[1]沈阳农业大学植物保护学院,沈阳110866

出　　处：《农药学学报》2020年第5期815-822,共8页Chinese Journal of Pesticide Science

摘　　要：通过1年10地的番茄和葡萄田间试验,采用QuEChERS-高效液相色谱-串联质谱(QuEChERS-HPLC-MS/MS)法,研究了氰霜唑及其主要代谢物4-氯-5-(4-甲苯基)-1H-咪唑-2腈(CCIM)在番茄和葡萄中的残留及消解动态,并进行了膳食暴露风险评估。结果表明:番茄在0.005~2 mg/kg、葡萄在0.005~1 mg/kg添加水平下,氰霜唑和CCIM在番茄和葡萄中的平均回收率分别为86%~105%和84%~105%,相对标准偏差(RSD)均小于10%。氰霜唑和CCIM在番茄和葡萄中的定量限均为0.005 mg/kg,满足农药残留限量标准的要求。氰霜唑在番茄和葡萄中的消解动态均符合一级反应动力学方程,在番茄和葡萄中的半衰期分别为4.9~10.3 d和8.6~11.9 d。氰霜唑在番茄和葡萄鲜果中膳食暴露风险指数均小于100%,膳食暴露风险处于可接受水平。农药的暴露水平对于不同年龄段和不同性别人群表现不同,总体分析,膳食暴露量随年龄的增加逐渐降低,其中儿童(2~4岁)膳食暴露量最高,同年龄段女性的膳食暴露量略高于男性。The residue and dissipation dynamics of cyazofamid and its main metabolite 4-chloro-5-ptolylimidazole-2-carbonitrile(CCIM)in tomato and grape were investigated by QuEChERS-high performance liquid chromatography-tandem mass spectrometry(QuEChERS-HPLC-MS/MS)method.Field experiments were conducted in ten sites for one year.And the dietary intake risk of cyazofamid was assessed.At three levels of 0.005 to 2 mg/kg(tomato)or 0.005 to 1 mg/kg(grape),the results showed that the average recoveries of cyazofamid and CCIM in tomato and grape were 86%-105%and 84%-105%,respectively,with RSD less than 10%.The quantitative limits(LOQ)for tomato and grape samples were both 0.005 mg/kg,which met the requirement of max residue limit of cyazofamid.The dissipation dynamics of cyazofamid in tomato and grape matrices fitted the first order kinetic equation,and the half-lives in tomato and grape were 4.9-10.3 d and 8.6-11.9 d,respectively.The dietary intake risk assessment indicated that the dietary exposure risk index of cyazofamid in tomato and grape fruits were less than 100%,which indicated that the dietary exposure risk was at an acceptable level.The level of pesticide exposure was different for different age and gender groups.In general,dietary exposure gradually decreased with the increase of age.Among them,children(2-4 years old)had the highest dietary exposure,and females in the same age groups had slightly higher dietary exposure than men.

关 键 词：氰霜唑 代谢物 CCIM 番茄 葡萄 残留 消解 膳食暴露风险评估 

分 类 号：S482.2[农业科学—农药学] TQ450.263[农业科学—植物保护]