环氧合酶2、雌激素受体、孕激素受体与子宫内膜息肉的形成及绝经后子宫内膜息肉恶变率增高的相关性研究  

Study on the correlation between COX-2,ER,PR and the formation of endometrial polyps and the increased malignant change rate of endometrial polyps after menopause

作　　者：张妙 吴如英 尹淑萍 杨丽敏 杨杰 孟翻龙 解增强 Zhang Miao;Wu Ruying;Yin Shuping;Yang Limin;Yang Jie;Meng Fanlong;Xie Zengqiang(Depurtment of Obstetrics and Cynecology,the People.8 Hosptal of Changxing County,Zhejiang 313100,China;Deportment of Pathology,the Peoples Hospial of Changxing County,Zhejiang 313100,China)

机构地区：[1]浙江省长兴县人民医院妇产科,313100 [2]浙江省长兴县人民医院病理科,313100

出　　处：《中国基层医药》2020年第20期2448-2452,共5页Chinese Journal of Primary Medicine and Pharmacy

基　　金：浙江省湖州市第二批科技计划研究项目(2017GY60)。

摘　　要：目的 探讨环氧合酶2 (COX-2)、雌激素受体(ER)、孕激素受体(PR)与子宫内膜息肉的形成及绝经后子宫内膜息肉恶变率增高的相关性.方法 选取2018年1月至2019年1月长兴县人民医院收治的绝经后女性患者160例,根据疾病不同分为子宫内膜息肉组(83例)、卵巢切除组(42例)、正常绝经组(35例).对三组的COX-2、ER、PR水平进行检测.比较三组COX-2在间质细胞、腺上皮细胞中的表达情况、ER在间质细胞、腺上皮细胞中的表达情况、PR在间质细胞、腺上皮细胞中的表达情况、分析COX-2、ER、PR与子宫内膜息肉恶变率增高的相关性.结果 子宫内膜息肉组中COX-2在间质细胞、腺上皮细胞中的阳性表达率(16.9%、30.1%)高于正常绝经组(0.0%、11.4%)、卵巢切除组(4.8%、7.1%)(x2=4.568、5.806,均P<0.05);三组ER在间质细胞、腺上皮细胞中的表达情况差异均无统计学意义(x2=1.333、1.412,均P>0.05);子宫内膜息肉组PR在间质细胞、腺上皮细胞中的表达低于正常绝经组、卵巢切除组(x2=4.890、5.022,均P<0.05);COX-2与子宫内膜息肉恶变率增高呈正相关(r=4.335,P<0.05),PR与子宫内膜息肉恶变率增高呈负相关(r=-4.256,P<0.05),ER与子宫内膜息肉恶变率增高无明显相关性(r=1.203,P>0.05).结论 COX-2、PR与子宫内膜息肉的形成及绝经后子宫内膜息肉恶变率增高有明显的关系,而ER无明显相关,因此,对患者的COX-2、PR水平进行检测,有利于为临床相关治疗提供一定的科学依据.Objective To investigate the correlation between clooxygenase-2(C0X-2),estrogen receptor(ER),progesterone receptor(PR)and the formation of endometrial polyps and the increased malignant rate of postmenopausal endometrial polyps.Methods From January 2018 to January 2019,a total of 160 postmenopausal women treated in the Peoples Hospital of Changxing County were selected and divided into endometrial polyps group(83 cases)and oothectomy group(42 cases),normal menopause group(35 cases)according to different diseases.The levels of COX-2,ER,PR in the three groups were measured.The expression of COX-2 in mesenchymal cells and glandular epithelial cells,the expression of ER in mesenchymal cells and glandular epithelial cells,the expression of PR in mesenchymal cells and glandular epithelial cells in the three groups were compared,and the correlation between Cox-2,ER,PR and increased malignant rate of endometrial polyps was analyzed.Results'The positive expression ratesof Cox-2 in mesenchymal cells and glandular epithelial cells in the endometrial polyps group(16.9%,30.1%)were higher than those in the normal menopause group(0.0%,11.4%)and the oothectomy group(4.8%,7.1%)(χ2=4.568,5.806,all P<0.05).There were no stistically significant diferences in the expression of ER in mesenchymal cells and glandular epithelial cells among the three groups(χ2=I.333.1.412,all P>0.05).The expression of PR in mesenchymal cells and glandular epithelial cells in the endometrial polyps group was lower than that in the normal menopause group and the oothectomy group(χ2=4.890,5.022,all P<0.05).COX-2 was positively crrelated with the increase in maligmant rale of endometrial polyps(r=4.335,P<0.05),PR was negatively correlated with an increase in the malignant rate of endometrial polyps(r=-4.256,P<0.05),and ER had no signifieant correlation with an increase in the malignant rate of endometrial polyps(r=1.203,P>0.05).Conclusion COX-2 and PR are significantly related to the formation of endometrial polyps and the increase in malignant rate of po

关 键 词：绝经后期 子宫内膜 息肉 子宫内膜肿瘤 环氧合酶2 受体 雌激素 孕激素类 女(雌)性 

分 类 号：R711.74[医药卫生—妇产科学]