地塞米松磷酸钠注射液致暂时性尿失禁  

Temporary urinary incontinence due to dexamethasone sodium phosphate injection

作　　者：姜坤 宋琳婧 游丽娜 Jiang Kun;Song Linjing;You Lina(Department of Pharmacy,Yunnan Kungang Hospital,Kunming 650302,China;Department of Oncology,Yan′an Hospital of Kunming City,Kunming 650051,China;Department of Pharmacy,Yan′an Hospital of Kunming City,Kunming 650051,China)

机构地区：[1]云南昆钢医院药学部,昆明650302 [2]昆明市延安医院肿瘤科,650051 [3]昆明市延安医院药学部,650051

出　　处：《药物不良反应杂志》2020年第9期529-530,共2页Adverse Drug Reactions Journal

摘　　要：1例64岁女性子宫内膜癌患者化疗前为防止紫杉醇过敏反应,予以地塞米松磷酸钠注射液10 mg入5%葡萄糖注射液100 ml静脉滴注,约30 min滴注完毕,输注过程中患者无不适。约2 h后,患者出现尿失禁,无尿急、尿痛,此后逐渐缓解。患者第2次静脉滴注地塞米松磷酸钠注射液后2 h,尿失禁症状复现。将静脉滴注地塞米松磷酸钠注射液改为口服地塞米松片后尿失禁症状减轻。考虑患者的暂时性尿失禁很可能与地塞米松磷酸钠有关。A 64⁃year⁃old female patient with endometrial cancer received an IV infusion of dexamethasone sodium phosphate injection 10 mg dissolved in 5%glucose injection 100 ml before chemo⁃therapy to prevent allergic reaction induced by paclitaxel.The infusion was finished within about 30 minutes and the patient had no discomfort during the infusion.About 2 hours later,the patient developed urinary incontinence without urgent and painful urination,which gradually disappeared.Two hours after the second intravenous infusion of dexamethasone sodium phosphate injection,urinary incontinence recurred.After the intravenous infusion of dexamethasone sodium phosphate injection was replaced by oral dexamethasone tablets,the symptoms of urinary incontinence were alleviated.It was considered that the temporary urinary incontinence was probably related to dexamethasone sodium phosphate.

关 键 词：地塞米松 尿失禁 药物相关副作用和不良反应 

分 类 号：R969[医药卫生—药理学]