白杨素衍生物的生物活性研究进展  

Research Progress on Biological Activity of Chrysin Derivatives

作　　者：储丽莎 彭露 黄伟军 张亚林 马春雨 朱伟 闻振 CHU Li-sha;PENG Lu;HUANG Wei-jun;ZHANG Ya-lin;MA Chun-yu;ZHU Wei;WEN Zhen(College of Pharmacy,Anhui University of Chinese Medicine,Anhui Hefei 230012,China)

机构地区：[1]安徽中医药大学药学院,安徽合肥230031

出　　处：《广州化工》2020年第20期13-15,35,共4页GuangZhou Chemical Industry

基　　金：2019年安徽省大学生创新创业教育训练计划项目(201910369045)。

摘　　要：白杨素是一种具有广泛生物活性的黄酮类化合物,主要存在于紫葳科植物木蝴蝶的种子、茎皮中。研究表明,其具有抗肿瘤、改善体重和脂质代谢作用、抗抑郁、神经保护作用、治疗皮肤病等广泛的生物活性。但因其结构导致其水溶性差,胃肠道吸收效果不理想等因素,导致其临床应用受限。本文主要综述近年来白杨素衍生物的活性研究进展,以期有益于白杨素的进一步研究。Chrysin is a kind of flavonoid with extensive bioactivity,which is mainly found in the seeds and stem skins of the Bignoniaceae Wood Butterfly.Studies have shown that it has a wide range of biological activities,such as antitumor,weight improvement and lipid metabolism,anti-depression,neuroprotective effect,and treatment of skin diseases.However,due to its poor water-solubility and unsatisfactory gastrointestinal absorption,its clinical application is limited.The research progress on the activity of the derivatives of alicin in recent years was reviewed in order to benefit the further research of chrysin.

关 键 词：白杨素衍生物 结构修饰 生物活性 

分 类 号：O625.15[理学—有机化学]