25例新型冠状病毒肺炎患者的临床特征分析  

Analysis the clinical characteristics for 25 patients with COVID-19

作　　者：王义[1] 李建武 王辉[3] 樊华峰 Wang Yi;Li Jianwu;Wang Hui;Fan Huafeng(The Neonatal Intensive Care Unit,Xi′an Children′s Hospital,Xi′an 710003,China;Department of Radiology,the Eighth Hospital,Xi′an 710061,China;Department of Paediatric,the Ziyang County People′s Hospital of Shaanxi Province,Ankang 725300,China;Department of Cardiovascular Medicine,the Fuping County Hospital,Shaanxi Province,Weinan 711700,China)

机构地区：[1]西安市儿童医院NICU,710003 [2]西安市第八医院影像科,710061 [3]陕西省紫阳县人民医院儿科,安康725300 [4]陕西省富平县医院心血管内科,渭南711700

出　　处：《国际呼吸杂志》2020年第19期1475-1480,共6页International Journal of Respiration

摘　　要：目的:探寻新型冠状病毒肺炎(COVID-19)患者的临床特征。方法:收集2020年2月24日前在西安市第八医院、紫阳县人民医院确诊并治愈出院的COVID-19感染患者25例,回顾性分析患者临床基线资料及入院24 h内检验指标,将确诊患者分成高龄组(≥55岁)、低龄组(<55岁),统计2组各变量差异,同时对2组患者出院前3 d的临床检验指标进行组间统计。结果:2组患者合并症、入住重症监护病房比率、氧疗、白细胞、淋巴细胞、CD3^+、CD3^+CD4^+、血清谷丙转氨酶、血清谷草转氨酶、血清乳酸脱氢酶、血清脑钠肽比较,差异均有统计学意义(P值均<0.05),肌红蛋白、D-二聚体、红细胞沉降率及各感染相关指标方面差异均无统计学意义(P值均>0.05);治疗后,2组患者临床检验指标D-二聚体、CRP、血清乳酸脱氢酶、血清脑钠肽差异均有统计学意义(P值均<0.05)。结论:COVID-19感染患者随着年龄的增加,脏器功能受损的风险性可能会增加。Objective To explore the clinical characteristics of patients with COVID-19.Methods Patients with COVID-19 who were discharged from Ziyang County People′s Hospital of Shaanxi and the Eighth Hospital Xi′an before February 24,2020;and they all are cured.The study is retrospectively.Clinical baseline data of the patients and test indicators within 24 hours of admission were collected.Diagnosed patients were divided into two groups at the age of 50 years old as the cut-off point,and the differences of variables between the two groups were calculated.At the same time,intergroup statistics were made on the clinical test indexes of the two groups of patients 3 days before discharge.Results There were statistical differences in the rate of oxygen therapy on leukocyte and lymphocyte,CD3+,CD3+CD4+,alanine aminotransferase,aspartate transaminase,lactate dehydrogenase,brain natriuretic peptide(all P<0.05),and no statistical differences in myoglobin D-dimmer and erythrocyte sedimentation rate and infection indexes(all P>0.05).After treatment,There were statistically significant differences in the clinical indicators of D-dimer,CRP,serum lactate dehydrogenase and serum brain natriuretic peptide between the two groups(all P<0.05).Conclusions Patients with COVID-19 are more likely to have impaired visceral function with their age.

关 键 词：乳酸脱氢酶类 脑钠肽 D-二聚体 

分 类 号：R563.1[医药卫生—呼吸系统]