辐射固化可生物降解聚氨酯丙烯酸酯的合成及体外药物释放  

Synthesis and Drug Delivery of Radiation Curable and Biodegradable Polyurethane-Acrylate

作　　者：汤莉 冯学鹏 任文惠 徐德锋[2] 孙一新 盛扬 张嵘 Li Tang;Xuepeng Feng;Wenhui Ren;Defeng Xu;Yixin Sun;Yang Sheng;Rong Zhang(School of Materials Science&Engineering,Changzhou University;School of Pharmaceutical&Life Sciences,Changzhou University,Changzhou 213164,China)

机构地区：[1]常州大学材料科学与工程学院 [2]常州大学制药与生命科学学院,江苏常州213164

出　　处：《高分子材料科学与工程》2020年第8期138-145,共8页Polymer Materials Science & Engineering

基　　金：国家自然科学基金资助项目(21374012);江苏省2017年“双创团队”。

摘　　要：通过分子设计以聚乙二醇(PEG M_w1000)引发L-丙交酯(L-LA)开环聚合得到嵌段聚醚酯二醇(PLLA-PEG-PLLA,PLEL),再与异氰酸酯(异佛尔酮二异氰酸酯(IPDI)、六亚甲基二异氰酸酯(HDI)和甲基丙烯酸羟乙酯(HEMA))反应得到端基为双键的预聚物,采用红外光谱和核磁共振氢谱对其结构和组成进行表征。经UV固化得到聚氨酯丙烯酸酯(PUA)材料。增加PLLA链段含量,材料的T_g提高,吸水率和降解速率下降。PUA膜采用浸泡法包载药物,药物释放分析表明,包载四环素(TC)的PUA具有缓释功能,可持续释药达164 h,且可抑制细菌生长达24 h,有应用于植入体或医疗设备抗菌涂层的潜力。Polyether ester triblock diols(PLLA-PEG-PLLA,PLEL)were synthesized by the ring opening polymerization of L-lactide(L-LA)and polyethylene glycol(PEG M_w1000)through molecular design.They were used as soft segment for the preparation of double bond-terminated prepolymer with diisocyanates(isophorone diisocyanate(IPDI)and hexamethylene diisocyanate(HDI))and hydroxyethyl methacrylate(HEMA),which were analyzed by GPC and FT-IR.Polyurethane acrylate(PUA)was applied to UV initiated polymerization.The results show that with increasing PLLA length in PLEL-diols,the glass transition temperature is increased,while the water absorption and biodegradation rate are decreased.The PUA membranes were then used to load tetracycline(TC)antibiotic to perform a prolonged release process for 164 h.The TC loaded films releas drug which diffused and spread to the culture gel and preventing from the growth of the bacteria around the membranes for 24 h.It is found that these drug loaded polymers would be used as medical device or implant coating for controlled drug release.

关 键 词：聚醚酯 聚氨酯丙烯酸酯 紫外光固化 药物释放 

分 类 号：TQ460.4[化学工程—制药化工]