双重pH响应超轻度交联支化聚合物纳米材料的合成及对大黄素的载药应用  

Synthesis and Application of Dual pH-Responsive Lightly-Crosslinked Branched Copolymer Nanoparticles in Loading and pH-Triggered Release of Rheum Emodin

作　　者：谢贤莉 张培松 刘春华 何涛 Xianli Xie;Peisong Zhang;Chunhua Liu;Tao He(School of Chemistry and Chemical Engineering,Hefei University of Technology,Hefei 230009,China;General Surgery Department of Anhui Provincial Armed Police Corps Hospital,Hefei 230061,China)

机构地区：[1]合肥工业大学化学与化工学院,安徽合肥230009 [2]武警安徽省总队医院普外三科,安徽合肥230061

出　　处：《高分子材料科学与工程》2020年第8期146-151,157,共7页Polymer Materials Science & Engineering

基　　金：国家自然科学基金面上项目(21574035)。

摘　　要：采用寡聚乙二醇甲基丙烯酸酯(OEGMA)、甲基丙烯酸二乙胺乙酯(DEAEMA)和原酸酯结构单元构建超轻度交联支化共聚物PODO及其纳米材料,并对大黄素(RE)的载药/释药进行了研究。PODO聚合物纳米材料的制备方法简单,无需自组装,且具有双重pH响应性:在中性水液中稳定,而在pH 5.5时,纳米颗粒会发生先变大后解离的双重响应过程。以大黄素为模型药物,进行了相关载药及pH响应释药研究,包载率达到35.2%。释药实验表明,在pH 7.0时,药物纳米颗粒相对稳定;在pH 5.5时,经48 h药物释放率达87%。Oligomer ethylene glycol methacrylate(OEGMA),diethylamine ethyl methacrylate(DEAEMA)and ortho ester were employed to build the lightly-crosslinked branched copolymer(BP).Polymer nanoparticles could be prepared directly from BP after dissolving the polymer in water,which exhibit dual pH-responsiveness:nanoparticles are stable at pH 7.0,and undergo an expanding-to-decompose process when pH drops down to 5.5.The branched copolymer nanoparticles were used for the loading of hydrophobic rheum emodin(RE),and the loading ratio approaches 35.2%.Due to the dual pH-responsiveness,87%of RE is released at pH 5.0 after 48 h.As a contrast,only 21%of RE is released at pH 7.0.This study has impact on the synthesis of stimuli-responsive polymer nanoparticles together with the application in drug delivery.

关 键 词：聚合物纳米材料 原酸酯 双重pH响应 大黄素 药物纳米颗粒 

分 类 号：TQ460.4[化学工程—制药化工]