血清铁蛋白在幼年特发性关节炎活动性评估中的应用价值  

Application Value of Serum Ferritin in Assessing Activity of Juvenile Idiopathic Arthritis

作　　者：储卫红[1] 彭韶[1] 张曼[1] 马莹莹[1] 高艺伟[1] 徐莉燕[1] 高源[1] 苗雪艳 CHU Wei-hong;PENG Shao;ZHANG Man;MA Ying-ying;GAO Yi-wei;XU Li-yan;GAO Yuan;MIAO Xue-yan(Department of Pediatrics,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院儿科,河南郑州450052

出　　处：《河南医学研究》2020年第28期5196-5199,共4页Henan Medical Research

基　　金：河南省高等学校重点科研项目(18A320013)。

摘　　要：目的探讨血清铁蛋白(SF)水平在幼年特发性关节炎(JIA)活动性评估中的应用价值。方法选取2015年1月至2019年12月郑州大学第一附属医院收治的143例JIA患儿。检测SF、红细胞沉降率(ESR)和C反应蛋白(CRP)水平。通过临床评估和幼年关节炎疾病活动评分27(JADAS27)对疾病活动性进行评估。按JIA不同亚型,即全身型JIA(sJIA)、多关节型JIA(polyJIA)、少关节型JIA(oligJIA)、与附着点炎症相关的关节炎(ERA),将患儿分为全身型组(60例)、多关节型组(27例)、少关节型组(35例)、ERA组(21例)。比较4组疾病活动期SF升高率和疾病无活动期SF升高率。分析疾病活动期JIA不同亚型SF与ESR、CRP和JADAS27的相关性。结果 (1)疾病活动期,4组SF升高率比较,差异有统计学意义(P<0.05)。全身型组SF升高率高于其他3组(P<0.008)。多关节型组、少关节型组、ERA组SF升高率两两比较,差异无统计学意义(P>0.008)。(2)疾病无活动期,4组SF升高率比较,差异无统计学意义(P>0.05)。(3)疾病活动期,sJIA患儿SF与ESR、CRP和JADAS27呈正相关(P<0.05)。疾病活动期,polyJIA、oligJIA、ERA患儿的SF与ESR、CRP和JADAS27均无关(P>0.05)。结论疾病活动期,与polyJIA、oligJIA和ERA患儿比较,sJIA患儿更可能出现SF升高。sJIA患儿SF水平与ESR、CRP和JADAS27呈正相关。SF可被用来评估sJIA的疾病活动性。Objective To explore the application value of the level of serum ferritin(SF)in assessing activity of juvenile idiopathic arthritis(JIA).Methods A total of 143 children with JIA were recruited who were hospitalized in the First Affiliated Hospital of Zhengzhou University from January 2015 to December 2019.The levels of SF,erythrocyte sedimentation rate(ESR)and C reactive protein(CRP)were tested.The activity of disease was assessed by clinical assessment and juvenile arthritis disease activity score 27(JADAS27).According to different subtypes of JIA,namely systemic JIA(sJIA),polyarticular JIA(polyJIA),oligoarticular JIA(oligJIA),and enthesitis-related arthritis(ERA),the patients were divided into systemic group(60 cases),polyarticular group(27 cases),oligarticular group(35 cases)and ERA group(21 cases).The rate of elevated SF in active disease and in inactive disease were compared among 4 groups.The correlation of SF with ESR,CRP and JADAS27 was analyzed in different subtypes of JIA during the active period of disease.Results(1)In the active stage of disease,there was a statistical difference in the rate of elevated SF among 4 groups(P<0.05).The rate of elevated SF in systemic group was higher than that in other 3 groups(P<0.008).Pairwise comparison of the rate of elevated SF in polyarticular group,oligarticular group and ERA group showed no statistically differences(P>0.008).(2)During the inactive period,the rate of elevated SF among 4 groups had no statistical difference(P>0.05).(3)In the active stage of disease,positive correlation was found between SF and ESR,CRP and JADAS27 in the patients with sJIA(P<0.05).No correlations were found between SF and ESR,CRP and JADAS27 in the active stage of polyJIA,oligJIA and ERA.Conclusion In the active stage of disease,the patients with sJIA are more likely to have elevated SF compared with polyJIA,oligJIA and ERA.The level of SF in the children with sJIA is positively correlated with ESR,CRP and JADAS27.SF may be used to assess the disease activity of sJIA.

关 键 词：幼年特发性关节炎 血清铁蛋白 疾病活动性 

分 类 号：R725.9[医药卫生—儿科]