影像学评估高选择性神经根封闭辅助退行性脊柱侧凸短节段固定融合的效果  

Imaging evaluation of short-segment fixation and fusion for degenerative lumbar scoliosis assisted by highly selective nerve root block

作　　者：梁彦 赵永飞[2] 徐帅[1] 朱震奇[1] 王凯丰[1] 刘海鹰[1] 毛克亚[2] Liang Yan;Zhao Yongfei;Xu Shuai;Zhu Zhenqi;Wang Kaifeng;Liu Haiying;Mao Keya(Department of Spine Surgery,People’s Hospital of Peking University,Beijing 100853,China;Department of Orthopedics,Chinese PLA General Hospital,Beijing 100042,China)

机构地区：[1]北京大学人民医院脊柱外科,北京市100853 [2]中国人民解放军总医院骨科,北京市100042

出　　处：《中国组织工程研究》2021年第9期1423-1427,共5页Chinese Journal of Tissue Engineering Research

基　　金：国家自然基金面上项目(51772328),项目名称:一种载免疫佐剂的磁性骨水泥系统在交变磁场中产生的肿瘤疫苗作用及其机制研究,项目参与者:毛克亚;国家重点研发计划项目(2016YFC0105606),项目负责人:王凯丰。

摘　　要：背景:关于成人退行性腰椎侧凸的治疗选择中,采用短节段固定或长节段固定仍存在较大的争议。目的:探讨高选择性神经根封闭辅助下对成人退行性腰椎侧凸行短节段固定精准治疗的有效性和可行性。方法:选择2014年5月至2017年9月301医院和北大人民医院收治的35例退行性腰椎侧凸患者,其中男14例,女21例,年龄(64.2±8.1)岁,所有患者均在高选择性神经根封闭下确定固定节段,进行经椎间孔腰椎间融合治疗。术后随访评估腰腿部目测类比评分与Oswestry残疾指数,通过影像学检查获得Cobb角、腰椎前凸角、骶骨倾斜角和骨盆倾斜角数据与椎间融合情况,记录并发症。试验获得301医院和北大人民医院伦理委员会批准。结果与结论:①35例患者中27例行单节段微创经椎间孔腰椎融合,5例行双节段微创经椎间孔腰椎融合,3例行三节段微创经椎间孔腰椎融合;②35例患者获得平均(25.6±1.5)个月随访,均获Ⅰ级融合,3个月内出现硬膜撕裂脑脊液漏3例,下肢肌间静脉血栓1例,肺炎1例,伤口脂肪液化1例;3个月后出现邻近节段退变1例;无神经损伤或不愈合,无螺钉或钛棒断裂;③35例患者末次随访的腰腿部目测类比评分、Oswestry残疾指数、Cobb角、腰椎前凸角、骶骨倾斜角和骨盆倾斜角均较术前明显改善(P<0.01);④结果表明,高选择性神经根封闭辅助下对退行性腰椎侧凸患者行短节段固定精准治疗可取得较好的临床疗效。BACKGROUND:Short-or long-segment fixation is still controversial in the treatment of adult degenerative lumbar scoliosis.OBJECTIVE:To investigate the effectiveness and feasibility of accurate treatment of short-segment fixation in adult degenerative lumbar scoliosis patients assisted by highly selective nerve root block.METHODS:Thirty-five patients with adult degenerative lumbar scoliosis treated in Chinese PLA General Hospital and People’s Hospital of Peking University from May 2014 to September 2017 were analyzed retrospectively,including 14 males and 21 females aged(64.2±8.1)years.The fixation segments were determined by a highly selective nerve root block.All patients were subjected to transforaminal lumbar interbody fusion.During the follow-up,visual analogue scale score and Oswestry disability index were evaluated.Parameters including lumbar curvature Cobb angle,lumbar lordosis angle,sacral slope,and pelvic tilt and interbody fusion condition were obtained by imaging;and complications were recorded.This study was approved by the Ethics Committee of Chinese PLA General Hospital and People’s Hospital of Peking University.RESULTS AND CONCLUSION:(1)Of the 35 patients,27 underwent single-segment minimally invasive transforaminal lumbar fusion,5 underwent doublesegment minimally invasive transforaminal lumbar fusion,and 3 underwent three-segment minimally invasive transforaminal lumbar fusion.(2)The follow-up time of 35 patients was(25.6±1.5)months.All patients achieved the grade I fusion.Within 3 months,there were 3 cases of dural tear and cerebrospinal fluid leakage,1 case of lower-extremity muscular venous thrombosis,1 case of pneumonia and 1 case of wound fat liquefaction.Three months later,there was 1 case of adjacent segment degeneration;no nerve injury or nonunion,no screw or titanium rod breakage.(3)Visual analogue scale score,Oswestry disability index,Cobb angle,lumbar lordosis angle,sacral slope,and pelvic tilt at the last follow-up were significantly improved in 35 patients compared with those be

关 键 词：骨 固定 植骨 腰椎侧凸 选择性 神经根封闭 短节段固定 椎间融合 

分 类 号：R459.9[医药卫生—治疗学] R682.3[医药卫生—临床医学]