COVID-19与普通病毒性肺炎的临床特征分析  

Analysis of Clinical Characteristics of COVID-19 and Common Viral Pneumonia

作　　者：丁雪 刘海燕[1] 胡安群[1] 徐云云 黄琼[1] DING Xue;LIU Hai-yan;HU An-qun;XU Yun-yun;HUANG Qiong(Department of Laboratory Medicine,Anqing Municipal Hospital,Anhui Medical University,Anqing246003,Anhui,China)

机构地区：[1]安徽医科大学附属安庆市立医院检验科,安徽安庆246003

出　　处：《医学信息》2020年第20期50-53,共4页Journal of Medical Information

基　　金：安徽省安庆市新型冠状病毒感染疫情应急科技计划项目(编号:2020Z1004)。

摘　　要：目的观察新型冠状病毒肺炎(COVID-19)和普通病毒性肺炎的血液炎症标志物、影像学检查、以及临床症状的差异,以选出更便捷的指标辅助诊断COVID-19。方法选取2020年1月23日~2月18日在安徽医科大学附属安庆医院住院的COVID-19患者83例作为实验组,另选择同期在安庆市立医院住院的普通病毒性肺炎患者14例为对照组,比较两组一般情况、临床症状、肺部CT特征,C反应蛋白(CRP)、降钙素原(PCT)、白细胞计数(WBC)、中性粒细胞计数(NEUT)和淋巴细胞计数(LY)等指标结果。结果实验组中发热、有痰、畏寒比例分别为72.29%、37.35%、30.12%,低于对照组的100.00%、50.00%、57.14%,差异有统计学意义(P<0.05);实验组肺部CT特征呈斑片状高密度影比例为13.25%,低于对照组的35.71%,差异有统计学意义(P<0.05);两组肺部CT呈磨玻璃样、索条状、磨玻璃+索条、斑片状+索条、磨玻璃+实变、正常、磨玻璃+斑片比例比较,差异无统计学意义(P>0.05);ROC曲线显示,各指标诊断COVID-19的曲线下面积顺序为0.641(LY)>0.544(WBC)>0.521(NEUT)>0.395(PCT)>0.296(CRP)。结论新型冠状病毒肺炎的临床特征与普通病毒性肺炎相似,两者CT表现也较为一致,PCT、CRP对诊断2019新冠肺炎感染的诊断价值低,WBC、NEUT对诊断2019新冠肺炎感染的诊断价值略低,LY对诊断2019新冠肺炎感染的诊断价值较高。Objective To observe the differences in blood inflammatory markers,imaging examinations,and clinical symptoms between the novel coronavirus pneumonia(COVID-19)and common viral pneumonia,so as to select more convenient indicators to assist in the diagnosis of COVID-19.Methods A total of 83 patients with COVID-19 who were hospitalized in Anqing Hospital of Anhui Medical University from January 23 to February 18,2020 were selected as the experimental group,and 14 patients with common viral pneumonia who were hospitalized in Anqing Municipal Hospital during the same period were selected as controlsgroup,compare the general conditions,clinical symptoms,lung CT characteristics,C-reactive protein(CRP),procalcitonin(PCT),white blood cell count(WBC),neutrophil count(NEUT)and lymphocyte count(LY)and other indicators.Results The proportions of fever,sputum,and chills in the experimental group were 72.29%,37.35%,and 30.12%,respectively,which were lower than those of the control group by 100.00%,50.00%,and 57.14%,the difference was statistically significant(P<0.05);The proportion of CT features showing patchy high-density shadows was 13.25%,which was lower than 35.71%of the control group,the difference was statistically significant(P<0.05);the lung CT of the two groups showed ground-glass,cord-like,ground-glass+The ratio of cords,patchy+cords,ground glass+consolidation,normal,ground glass+patches was not statistically significant(P>0.05);ROC curve shows the curve of each index for COVID-19 diagnosis the order of the lower area was 0.641(LY)>0.544(WBC)>0.521(NEUT)>0.395(PCT)>0.296(CRP).Conclusion The clinical features of novel coronavirus pneumonia were similar to those of ordinary viral pneumonia,and the CT findings of the two were relatively consistent.PCT and CRP had low diagnostic value for diagnosing 2019 novelcoronavirus pneumonia infection,while WBC and NEUT had slightly lower diagnostic value for diagnosing 2019 novelcoronavirus pneumonia infection LY had a high diagnostic value for diagnosing 2019 novelcoronaviruspneu

关 键 词：新型冠状病毒肺炎 炎症标志物 C反应蛋白 普通病毒性肺炎 

分 类 号：R563.1[医药卫生—呼吸系统]