外周血白介素38在慢性阻塞性肺疾病急性加重期中的表达及价值  

Expression and Value of Interleukin 38 in Peripheral Blood in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

作　　者：赵杰[1] 朱洪斌[1] ZHAO Jie;ZHU Hong-bin(Department of Respiratory Medicine,Chaohu Hospital,Anhui Medical University,Chaohu238000,Anhui,China)

机构地区：[1]安徽医科大学附属巢湖医院呼吸内科,安徽巢湖238000

出　　处：《医学信息》2020年第20期65-68,共4页Journal of Medical Information

摘　　要：目的探讨外周血白介素38(IL-38)在慢性阻塞性肺疾病急性加重期患者(AECOPD)中的表达水平及意义。方法收集2019年1月~2020年6月在安徽医科大学附属巢湖医院住院的AECOPD患者76例设为急性加重组,另收集同期稳定期COPD患者76例设为稳定组,健康体检者62名设为对照组,另根据GOLD指南和DOSE评分将急性加重组患者分为AB组、CD组、高危组及低危组,酶联免疫吸附法测定各组外周血IL-38表达水平,分析外周血IL-38在AECOPD患者中表达水平及其意义。结果急性加重组外周血IL-38水平高于稳定组和对照组,且稳定组高于对照组,差异有统计学意义(P<0.05);CD组外周血IL-38水平高于AB组,差异有统计学意义(P<0.05);高危组外周血IL-38水平高于低危组,差异有统计学意义(P<0.05);相关性分析显示,外周血IL-38与IL-6、CRP、mMRC、过去1年急性加重次数及DOSE评分呈正相关(r=0.412、0.377、0.233、0.330、0.247),与FEV1%预计值呈负相关(r=-0.226);多元回归分析显示,IL-6、CRP和过去1年急性加重次数是外周血IL-38的独立影响因素。结论外周血IL-38在慢性阻塞性肺疾病急性加重期患者中表达升高,且与体内炎性反应水平密切相关,可以作为急性加重的独立危险因素。Objective To investigate the expression level and significance of peripheral blood interleukin 38(IL-38)in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 76 AECOPD patients who were hospitalized in Chaohu Hospital Affiliated to Anhui Medical University from January 2019 to June 2020 were collected as acute recombination.In addition,76 patients with stable COPD during the same period were collected as stable group,and 62 healthy subjects were selectedas the control group,according to the GOLD guideline and DOSE score,the acute recombination patients were divided into AB group,CD group,high-risk group and low-risk group.The expression level of IL-38 in each group was determined by enzyme-linked immunosorbent assay,and the peripheral blood was analyzed.The expression level and significance of IL-38 in AECOPD patients.Results The level of IL-38 in the peripheral blood of acute recombination was higher than that of the stable group and the control group,and the stable group was higher than the control group,the difference was statistically significant(P<0.05);the peripheral blood IL-38 level of the CD group was higher than that of the AB group,the difference was statistically significant(P<0.05);the level of IL-38 in the peripheral blood of the high-risk group was higher than that of the low-risk group,the difference was statistically significant(P<0.05);correlation analysis showed that the peripheral blood IL-38 and IL-6,CRP,mMRC,the number of acute exacerbations in the past year,and DOSE score were positively correlated(r=0.412,0.377,0.233,0.330,0.247),and negatively correlated with FEV1%predicted value(r=-0.226);multiple regression analysis showed that,IL-6,CRP and the number of acute exacerbations in the past year are independent influencing factors of peripheral blood IL-38.Conclusion The expression of IL-38 in peripheral blood was elevated in patients with acute exacerbation of chronic obstructive pulmonary disease,and was closely related to the level of infl

关 键 词：白介素38 慢性阻塞性肺疾病 炎症介质 急性加重 

分 类 号：R563.9[医药卫生—呼吸系统]