开颅夹闭术与血管内栓塞术治疗高危颅内动脉瘤破裂患者的疗效比较  

Comparison of the Curative Effect of Craniotomy and Endovascular Embolization on High-risk Patients with Ruptured Intracranial Aneurysm

作　　者：廖伟[1] 蔡崇明 罗穆云[1] 邱传珍[1] 杨少春[1] LIAO Wei;CAI Chong-ming;LUO Mu-yun;QIU Chuan-zhen;YANG Shao-chun(Department of Neurosurgery,the First Affiliated Hospital of Gannan Medical College,Ganzhou 341000,Jiangxi,China)

机构地区：[1]赣南医学院第一附属医院神经外科,江西赣州341000

出　　处：《医学信息》2020年第20期104-106,共3页Journal of Medical Information

摘　　要：目的比较开颅夹闭术与血管内栓塞术治疗高危颅内动脉瘤破裂患者临床疗效。方法选取2018年2月~2019年6月于我院接受治疗的85例高危颅内动脉瘤破裂患者为研究对象,依据随机数字表法分为对照组(42例)与观察组(43例)。对照组采用开颅夹闭术,观察组采用血管内栓塞术,比较两组术前、术后6 h及术后24 h时脑损伤指标[S100B蛋白、神经元特异性烯醇化酶(NSE)]水平及并发症发生情况。结果术前两组S100B蛋白、NSE水平比较,差异无统计学意义(P>0.05);术后6 h及术后24 h时,观察组S100B蛋白、NSE水平均低于对照组,差异有统计学意义(P<0.05);观察组术后并发症发生率(6.98%)高于对照组(26.19%),差异有统计学意义(P<0.05)。结论开颅夹闭术与血管内栓塞术均为临床治疗高危颅内动脉瘤破裂的有效方法,其中血管内栓塞术对患者脑损伤更小,且术后并发症发生率更低。Objective To compare the clinical efficacy of craniotomy and endovascular embolization in the treatment of patients with high-risk intracranial aneurysm rupture.Methods 85 patients with high-risk intracranial aneurysm rupture who were treated in our hospital from February 2018 to June 2019 were selected as the research objects,and were divided into the control group(42 cases)and the observation group(43 cases)according to the random number table method.The control group was operated with craniotomy and the observation group was operated with endovascular embolization.The two groups were compared with brain injury indexes[S100B protein,neuron-specific enolase(NSE)before operation,6 h after operation,and 24 h after operation]level and occurrence of complications.Results There was no statistically significant difference in the levels of S100B protein and NSE between the two groups before surgery(P>0.05);at 6 h and 24 h after surgery,the levels of S100B protein and NSE in the observation group were lower than those in the control group,the difference was statistically significant(P<0.05);the incidence of postoperative complications in the observation group(6.98%)was higher than that in the control group(26.19%),the difference was statistically significant(P<0.05).Conclusion Both craniotomy and endovascular embolization were effective methods for the clinical treatment of high-risk intracranial aneurysm rupture.Among them,endovascular embolization had less brain damage and lower postoperative complications.

关 键 词：颅内动脉瘤破裂 开颅夹闭术 血管内栓塞术 

分 类 号：R651.1[医药卫生—外科学]