脓毒症心律失常心肌离子通道机制及药物治疗的研究进展  

Research Advances in Mechanism of Myocardial Ion Channels and Drug Therapy in Sepsis Arrhythmia

作　　者：吕永 王龙[1] 王汉兵[2] 乐悦 LYU Yong;WANG Long;WANG Hanbing;LE Yue(Department of Anesthesiology,Renmin Hospital of Wuhan University,Wuhan 430060,China;Department of Anesthesiology,Foshan First People′s Hospital,Foshan 528000,China)

机构地区：[1]武汉大学人民医院麻醉科,武汉430060 [2]佛山市第一人民医院麻醉科,广东佛山528000

出　　处：《医学综述》2020年第19期3752-3757,共6页Medical Recapitulate

基　　金：国家自然科学基金(81772044)。

摘　　要：脓毒症是由感染引起的全身炎症反应综合征,脓毒症患者发病率和死亡率增加与心律失常的发生密切相关。在脓毒症危重患者中可出现阵发性室上性心动过速、心房颤动、心室颤动等多种不同类型的心律失常,而心律失常的发生常与心肌离子通道电流的改变密切相关。但目前的研究多集中于对脓毒症后心脏功能的改变,为了更好地了解脓毒症后心律失常的发生机制,即针对脓毒症后心律失常心肌离子通道的变化,并结合目前的药物治疗研究进展加以综述。Sepsis is a systemic inflammatory response syndrome caused by infection,and the increased morbidity and mortality of sepsis patients are closely related to the occurrence of arrhythmia.A variety of arrhythmias can occur in critically ill patients with sepsis,including paroxysmal supraventricular tachycardia,atrial fibrillation and ventricular fibrillation,etc.The occurrence of arrhythmia is often closely related to the change of myocardial ion channel current.However,most of the existing studies focus on the changes in heart function after sepsis.In order to better understand the mechanism of arrhythmia after sepsis,here reviews the changes of myocardial ion channels after sepsis and the progress of drug therapy.

关 键 词：脓毒症 心律失常 离子通道 药物治疗策略 

分 类 号：R631[医药卫生—外科学]