骨化三醇对脊柱结核患者维生素D代谢和骨密度影响的研究  

Effect of calcitriol on vitamin D metabolism and bone mineral density in patients with spinal tuberculosis

作　　者：章权[1] 魏威[1] 费骏[1] 韩贵和[1] 赖震[1] ZHANG Quan;WEI Wei;FEI Jun;HAN Guihe;LAI Zhen(Department of Orthopaedics,Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine,Hangzhou 310003,China)

机构地区：[1]浙江省中西医结合医院骨科,浙江杭州310003

出　　处：《中国现代医生》2020年第26期97-100,共4页China Modern Doctor

基　　金：浙江省杭州市科技发展计划重点专病专科项目(20160533B42);浙江省中医药科学研究基金项目(2016ZA 154)。

摘　　要：目的探讨骨化三醇对脊柱结核患者血清25(OH)D3、1,25(OH)2D3含量和BMD的影响。方法2016年1月~2018年12月在浙江省中西医结合医院骨科就诊,诊断为脊柱结核的患者共60例随机分为治疗组和对照组,治疗组加用骨化三醇软胶囊。观察治疗后4周、8周25(OH)D3、1,25(OH)2D3含量和BMD的变化。结果治疗后4周、8周,治疗组25(OH)D3和1,25(OH)2D3含量分别为(14.05±4.60)ng/L、(16.00±4.92)ng/mL和(21.01±4.97)ng/L、(23.88±4.77)ng/L,高于对照组的(11.16±3.94)ng/L、(11.75±4.10)ng/mL和(19.34±6.09)ng/L、(18.75±6.29)ng/L,且在治疗后8周时,差异有统计学意义(P<0.05);治疗后8周,治疗组腰椎和髋关节BMD分别为(0.96±0.28)g/cm2、(0.94±0.20)g/cm2,高于对照组的(0.81±0.19)g/cm2、(0.85±0.16)g/cm2,差异有统计学意义(P<0.05)。结论在脊柱结核治疗过程中补充骨化三醇可以提高血清25(OH)D3、1,25(OH)2D3含量,提升BMD。Objective To explore the effect of calcitriol on serum 25(OH)D3,1,25(OH)2D3 content and BMD in patients with spinal tuberculosis.Methods A total of 60 patients with spinal tuberculosis admitted to the Department of Orthopaedics,Zhejiang Provincial Hospital of Integrated Traditional Chinese and Western Medicine from January 2016 to December 2018 were randomly divided into treatment group and control group.The treatment group was supplemented with calcitriol soft capsule.The changes of 25(OH)D3,1,25(OH)2D3 content and BMD were observed at 4 weeks and 8 weeks after treatment.Results At 4 and 8 weeks after treatment,the levels of 25(OH)D3 and 1,25(OH)2D3 in the treatment group were(14.05±4.60)ng/mL,(16.00±4.92)ng/mL and(21.01±4.97)ng/mL,(23.88±4.77)ng/L,respectively,higher than(11.16±3.94)ng/mL,(11.75±4.10)ng/mL and(19.34±6.09)ng/mL,(18.75±6.29)ng/L in the control group,and the differences were statistically significant at 8 weeks after treatment(P<0.05).The BMD of lumbar vertebrae and hip joints in the treatment group were(0.96±0.28)g/cm2 and(0.94±0.20)g/cm2 respectively at 8 weeks after treatment,higher than(0.81±0.19)g/cm2,(0.85±0.16)g/cm2 in the control group,and the differences were statistically significant(P<0.05).Conclusion The addition of calcitriol during the treatment of spinal tuberculosis can increase serum 25(OH)D3 and 1,25(OH)2D3 levels and increase BMD.

关 键 词：结核 脊柱 骨化三醇 25-羟化维生素D3 骨密度 

分 类 号：R587.1[医药卫生—内分泌]