中医药解毒化瘀汤联合丙种球蛋白治疗川崎病临床效果  

Clinical effects of the Jiedu Huayu decoction plus gamma globulin on Kawasaki disease

作　　者：付爱学 孟英英 Fu Aixue

机构地区：[1]荣成市妇幼保健院,山东威海264300

出　　处：《中医临床研究》2020年第26期42-45,共4页Clinical Journal Of Chinese Medicine

摘　　要：目的:探讨给予川崎病患儿采用解毒化瘀汤联合丙种球蛋白治疗的临床效果。方法:选取本院于2018年6月-2019年5月收治的56例川崎病患儿为研究对象,根据患者所采用的治疗方案将其分为常规组(28例)和复合组(28例)。常规组患儿采用阿司匹林联合丙种球蛋白治疗,复合组患儿在常规组患儿的治疗基础上加用解毒化瘀汤治疗。观察对比两组患儿的治疗效果、症状消失时间、冠状动脉扩张率、炎症因子水平以及实验室相关指标。结果:复合组总有效率明显高于常规组(P<0.05);复合组患儿症状消失时间明显短于常规组,同时冠状动脉扩张率明显低于常规组(P<0.05)。复合组患儿治疗后的白细胞介素-6(Interleukin-6,IL-6)、白细胞介素-8(Interleukin-8,IL-8)、肿瘤坏死因子-α(Tumor Necrosis Factor-α,TNF-α)水平均低于常规组(P<0.05);治疗后复合组患儿的白细胞计数(White Blood Count,WBC)、血小板计数(Platelet Count,PLT)低于常规组(P<0.05)。结论:给予川崎病患儿采用解毒化瘀汤联合丙种球蛋白治疗的临床效果显著,能够有效改善患儿的临床症状,缩短症状消失时间,降低冠状动脉扩张率,促进其病情的早日康复。Objective:To explore the effect of the Jiedu Huayu decoction(解毒化瘀汤)plus gamma globulin on children with Kawasaki disease.Methods:According to the treatment plan adopted by the patients,56 children were divided into the routine group and compound group,28 cases in each.The routine group was treated with aspirin plus gamma globulin,and the compound group was treated with the Jiedu Huayu decoction more.Results:The total effective rate in the compound group was significantly higher than the routine group(P<0.05),and the disappearance time of symptoms in the compound group was significantly shorter,and the rate of coronary artery dilatation was significantly lower than the routine group(P<0.05).After treatment,the levels of IL-6,IL-8 and TNF-αin the compound group were lower,and WBC and PLT were lower than the routine group(P<0.05).Conclusion:The Jiedu Huayu decoction plus gamma globulin on children with Kawasaki disease shows a significant effect,can effectively improve the clinical symptoms,shorten the time of symptom disappearance,reduce the rate of coronary artery expansion,and promote the early recovery of the disease.

关 键 词：川崎病 解毒化瘀汤 丙种球蛋白 

分 类 号：R593[医药卫生—内科学]