19F-MR分子成像在靶向药物递送中的应用  

The application of 19F-MR molecular imaging in targeted drug delivery

作　　者：杨洁 李迎波 吴丽娜[1,2] 王凯[1,2] 杨丽丽[1,2] 孙夕林[1,2] YANG Jie;LI Yingbo;WU Li’na;WANG Kai;YANG Lili;SUN Xilin(TOF-PET/CT/MR Center,Fourth Hospital of Harbin Medical University,Harbin 150028,China;Molecular Imaging Research Center(MIRC),Harbin Medical University,Harbin 150028,China)

机构地区：[1]哈尔滨医科大学附属第四医院TOFPET/CT/MR中心,哈尔滨150028 [2]哈尔滨医科大学分子影像研究中心,哈尔滨150028

出　　处：《磁共振成像》2020年第10期954-956,960,共4页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金(编号:81627901);国家重点基础研究发展计划(编号:2015CB931800);黑龙江省高校分子影像重点实验室基金。

摘　　要：近年来,19F磁共振(19F magnetic resonance,19F-MR)分子成像在靶向药物递送领域展现了广阔的应用前景。鉴于19F原子较高的灵敏度以及体内缺乏内源性氟背景信号,以包括液态全氟化碳(perfluorocarbons,PFC)在内的许多纳米材料被研发和应用成为19F-MR成像的理想分子成像探针。19F-MR将分子成像技术与药物递送系统有机结合,从而实现对疾病的早期分子水平诊断、靶向治疗、疗效的实时监测与预后的精准判断。笔者对多种可用于19F-MR分子成像的纳米分子成像探针在靶向药物递送和智能化药物控释体系中的应用研究进展进行综述,讨论它们在该领域开展应用情况以及各自优缺点,以期为新型可用于19F-MR分子成像的多功能纳米材料的设计、制备、研发及应用提供理论依据和数据支撑。In recent years,19F magnetic resonance(19F-MR)molecular imaging represents a compelling option for studying targeted drug delivery.Due to the lack of endogenous fluorine in living organisms and the excellent sensitivity of 19F,nanomaterials including liquid perfluorocarbon(PFC)have been developed as ideal molecular imaging probes for 19F-MR imaging.The combination of 19F-MR imaging and targeted drug delivery presents an ideal modality for tumor-targeted theranostic,which improves the chances of diagnosis,therapy,efficacy monitoring and prognosis evaluation.In this review,we present our perspective on 19F-MR molecular imaging developments for the investigation of targeted drug delivery and stimuli-responsive drug release.And their application and the advantages and disadvantages are discussed,in order to provide theoretical basis and data support for the design,preparation,development and application of new multifunctional nanomaterials that can be used for 19F-MR molecular imaging.

关 键 词：19F磁共振分子成像 靶向药物递送 全氟化碳 诊疗一体化 智能化药物控释体系 

分 类 号：R445.2[医药卫生—影像医学与核医学] R943[医药卫生—诊断学]