SDF-1/CXCR4在子宫内膜异位症合并不孕患者子宫内膜表达  

Expression of SDF-1/CXCR4 of infertility women with endometriosis

作　　者：姚燕婷 赵霞[1] 宋勤[1] YAO Yanting;ZHAO Xia;SONG Qin(The Third People's Hospital of Hangzhou,Zhejiang Province,310009)

机构地区：[1]浙江省杭州市第三人民医院,310009

出　　处：《中国计划生育学杂志》2020年第10期1650-1653,共4页Chinese Journal of Family Planning

基　　金：浙江省杭州市科技局社会发展自主申报项目(20180533B62)。

摘　　要：目的:分析趋化因子受体4(CXCR4)与基质细胞衍生因子-1(SDF-1在子宫内膜异位症合并不孕患者的表达及意义。方法:选取本院2016年12月-2019年5月收治的子宫内膜异位症患者164例,根据病情分期及是否合并不孕症分组;另取同期行手术治疗的子宫肌瘤患者50例为对照组,比较各组内膜组织SDF-1、CXCR4、基质金属蛋白酶-9(MMP-9)及血管内皮生长因子(VEGF)水平,分析SDF-1、CXCR4与子宫内膜异位症合并不孕关系。结果:异位症患者SDF-1、CXCR4、MMP-9、VEGF水平随病情进展而增高且均高于对照组(P<0.05)。相关性分析发现,SDF-1、CXCR4表达水平均与MMP-9和VEGF表达水平呈正相关(r=0.683、0.701、0.695、0.674)。异位症组不孕患者SDF-1、CXCR4、MMP-9、VEGF水平均高于非不孕者(P<0.05)。结论:SDF-1、CXCR4可能通过参与子宫内膜增殖、侵袭过程而导致不孕发生。Objective: To investigate the expression and significance of chemokine receptors 4(CXCR 4) and stromal cell derived factors-1 of infertility women with endometriosis. Methods: From December 2016 to May 2019, 164 women with endometriosis were included and were divided into two groups according to whether complicated with infertility, and 50 women with uterine myoma who underwent surgical treatment during the same time were selected in control group. The levels of SDF-1, CXCR4, MMP-9, and VEGF of women were compared among the groups, and the relationship between the expression of the levels of SDF-1 and CXCR4 and endometriosis complicated with infertility was analyzed. Results: The levels of SDF-1, CXCR4, MMP-9, and VEGF of infertility women with endometriosis were significant higher than those of women in the control group(P<0 05). Correlation analysis showed that the expression levels of SDF-1 and CXCR4 were positively correlated with the expression levels of MMP-9 and VEGF(r=0.683, 0.701, 0.695, 0.674). The levels of SDF-1, CXCR4, MMP-9, and VEGF of infertile women with endometriosis were significant higher than those of women without infertile. Conclusion: CXCR4 may be lead to the the occurrence of infertility process of women with endometriosis by involving in endometrial proliferation and invasion.

关 键 词：子宫内膜异位症 不孕症 基质细胞衍生因子-1 趋化因子受体4 

分 类 号：R711.71[医药卫生—妇产科学] R711.6[医药卫生—临床医学]