妊娠中期f-β-HCG、AFP、uE3及Hcy与妊娠期高血压疾病关系  

Correlation of the levels of f-β-HCG, AFP,uE3,and Hcy and gestational hypertension during the second trimester of pregnancy

作　　者：杨琴[1] 蒋燕[1] 冯虹[1] YANG Qin;JIANG Yan;FENG Hong(Mianyang People's Hospital,Sichuan Province,621000)

机构地区：[1]四川省绵阳市人民医院,621000

出　　处：《中国计划生育学杂志》2020年第10期1676-1679,F0003,共5页Chinese Journal of Family Planning

基　　金：四川省绵阳市卫健委科研(201846)。

摘　　要：目的:探讨孕中期游离人绒毛膜促性腺激素β亚基(f-β-HCG)、甲胎蛋白(AFP)、游离雌三醇(uE3)和同型半胱氨酸(Hcy)检测在妊娠期高血压疾病的预判价值。方法:回顾性收集2019年1-12月在本院产科常规产前检查并分娩的孕妇,根据出院诊断分为妊娠期高血压疾病组(140例),孕期血压正常对照组(300例),对孕妇妊娠中期血清f-β-HCG、uE3、AFP和Hcy水平进行统计比较,应用工作者曲线(ROC曲线)及约登指数评判各血清学指标对妊娠期高血压疾病的预判价值。结果:高血压组血清f-β-HCG和Hcy水平高于对照组,uE3和AFP水平低于对照组(P<0.05);血清f-β-HCG、AFP、uE3、Hcy单独检测预测妊娠期高血压疾病的AUC值分别为0.651、0.325、0.377和0.868,特异性分别是80%、0%、1%和82%,敏感性为52%、100%、100%及82%,4项联合预测AUC值为0.931、特异性87%、敏感性90%。结论:妊娠期高血压疾病孕妇孕中期血清f-β-HCG和Hcy水平升高、AFP及uE3水平降低,该4项指标联合检测对妊娠期高血压疾病有较好的预测价值。Objective: To analyze the values of free human chorionic gonadotrophin subunit(f-β-HCG), alpha fetoprotein(AFP), uncon jugated estriol(uE3), and homocysteine(Hcy) for predicting gestational hypertension of women during the second trimester of pregnancy. Methods: The paper adopts retrospective analysis of the pregnant women from January 2019 to December 2019. 140 women with gestational hypertension were in study group and 300 women with head delivery were selected in control group. The levels of f-β-HCG, uE3, AFP, and Hcy of these women during the second trimester of pregnancy were compared between the two groups. Then the curve area under the ROC curve(AUC) and the Youden index were used to estimate the predictive value of serological index for gestational hypertension. Results: Serum f-β-HCG and Hcy levels of women in the study group were significant higher than those of women in the control group, but the levels of uE3 and AFP of women in the study group were significant lower(P<0.05). The AUC value of serum f-β-HCG level, AFP level, uE3 level or Hcy level for predicting gestational hypertension was 0.651, 0.325, 0.377 or 0.868, the specificity was 80%,0%, 1% or 82%, and the sensitivity was 52%, 100%, 100%, or 82%. The AUC value of combined serum f-β-HCG level, AFP level, uE3 level and Hcy level for predicting gestational hypertension was 0.931, the specificity was 87%, and the sensitivity was 90%. Conclusion: The serum f-β-HCG and Hcy levels of the women with gestational hypertension have increased significantly, while the levels of AFP and uE3 have decreased significantly, which could be used as a serological marker for predicting gestational hypertension.

关 键 词：妊娠期高血压疾病 妊娠中期 游离人绒毛膜促性腺激素β亚基 甲胎蛋白 游离雌三醇 同型半胱氨酸 

分 类 号：R714.246[医药卫生—妇产科学]