达格列净对胰岛素控制差的2型糖尿病患者疗效的影响  

Effect of Dagliazine on the Outcome of Type 2 Diabetes Patients with Poor Insulin Control

作　　者：何扬 张茜茜 李贤坤 刘玲萍 He Yang(Department of Endocrinology,Zhuhai People’s Hospital(Department of Endocrinology,Zhuhai Affiliated Hospital of Jinan University),Zhuhai Guangdong 519000)

机构地区：[1]珠海市人民医院内分泌科(暨南大学附属珠海医院内分泌科),广东珠海519000

出　　处：《黑龙江医药》2020年第5期994-997,共4页Heilongjiang Medicine journal

基　　金：珠海市科技计划医疗卫生项目(项目编号:20181117E030075)。

摘　　要：目的:分析达格列净对胰岛素控制差的2型糖尿病患者疗效的影响。方法:选取2019年1月—2019年12月我院收治的64例接受胰岛素联合降糖药治疗且血糖控制较差的2型糖尿病为研究对象,按数字随机表法分组。两组均接受常规降糖方案治疗,对照组30例加用安慰剂干预,观察组34例则加用达格列净干预,对比两组治疗前后血糖变化。结果:两组治疗前血糖及血脂水平比较差异无统计学意义(P>0.05),观察组治疗后TG水平较治疗前明显降低且低于对照组,差异有统计学意义(P<0.05),对照组治疗后各指标对比治疗前无显著变化(P>0.05);观察组治疗后HbA1c、FBG和2hPG水平低于治疗前,差异有统计学意义(P<0.05),观察组治疗后各指标水平低于对照组,差异有统计学意义(P<0.05)。结论:对胰岛素控制差的2型糖尿病患者加用达格列净可以有效地降低血糖和血脂水平,符合临床相关要求,值得应用。Objective:To analyze the effect of Dagrazine on the efficacy of Type 2 Diabetes patients with poor Insulin control.Methods:A total of 64 patients with type 2 diabetes who were treated with insulin and hypoglycemic drugs and had poor glycemic control in our hospital from January 2019 to December 2019 were selected as the research object and grouped according to the numerical random table method.Both groups received conventional hypoglycemic regimens,30 patients in the control group were treated with placebo,and 34 patients in the observation group were treated with dapagliflozin.Results:There was no statistically significant difference in blood glucose and lipid levels between the two groups before treatment(P>0.05).TG levels in the observation group were significantly lower than those in the control group after treatment(P<0.05).The levels of HbA1c,FBG and 2hPG in the observation group after treatment were lower than those before treatment,and the differences were statistically significant(P<0.05).The levels of all indicators in the observation group after treatment were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion:In patients with Type 2 Diabetes with poor Insulin control,the addition of Daggerazine can effectively reduce blood glucose and lipid levels,which meets the relevant clinical requirements and is worthy of application.

关 键 词：2型糖尿病 胰岛素 血糖 达格列净 

分 类 号：R587.1[医药卫生—内分泌]