中性粒细胞/淋巴细胞比值与不稳定型心绞痛行经皮冠状动脉介入治疗的关系  

Relationship between neutrophil-to-lymphocyte ratio and unstable angina during percutaneous coronary intervention

作　　者：郭刘治 牛千玉 杨喜山[1] GUO Liu-Zhi;NIU Qian-Yu;YANG Xi-Shan(Department of Cardiology,First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,Henan Province,China)

机构地区：[1]河南科技大学第一附属医院心血管内科,河南洛阳471000

出　　处：《中华老年多器官疾病杂志》2020年第10期749-753,共5页Chinese Journal of Multiple Organ Diseases in the Elderly

摘　　要：目的探讨中性粒细胞/淋巴细胞比值(NLR)与不稳定型心绞痛(UAP)患者需行经皮冠状动脉介入(PCI)治疗的关系。方法选择2018年1月至2019年6月河南科技大学第一附属医院心血管内科收治的260例UAP患者为研究对象,根据冠状动脉造影结果,分为需行PCI组167例和无需行PCI组93例。收集2组患者的临床资料并进行比较。采用SPSS 24.0软件进行数据处理。采用logistic回归法分析UAP患者需行PCI治疗的危险因素。受试者工作特征(ROC)曲线分析NLR对UAP患者需行PCI治疗的诊断价值。结果2组患者年龄、糖尿病史、中性粒细胞、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、NLR水平比较,差异均有统计学意义(P<0.05)。Spearman相关性分析显示,NLR与UAP患者需行PCI治疗呈正相关(r=0.353,P<0.001)。多因素logistic回归分析显示NLR是UAP患者需行PCI治疗的独立危险因素(OR=1.982,95%CI 1.168~3.362)。ROC曲线分析显示,NLR预测UAP患者需行PCI治疗的曲线下面积为0.713(95%CI 0.651~0.776)。结论NLR可作为UAP患者需行PCI治疗的预测指标之一。Objective To explore the relationship between neutrophil-to-lymphocyte ratio(NLR)and percutaneous coronary intervention(PCI)in the patients with unstable angina pectoris(UAP).Methods A total of 260 UAP patients admitted to the Department of Cardiology of the First Affiliated Hospital of Henan University of Science and Technology from January 2018 to June 2019 were enrolled in this study.According to the results of coronary angiography,they were divided into PCI group(n=167)and the group without the need for the procedure(n=93).The clinical data were collected and compared between the two groups.SPSS statistics 24.0 was used for data processing.Logistic regression analysis was employed to analyze the risk factors for PCI in UAP patients.Receiver operating characteristic(ROC)curve was plotted to analyze the diagnostic value of NLR for UAP patients who needed PCI.Results There were statistical differences between the two groups in age,gender,history of diabetes mellitus,neutrophil count,levels of total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C),and NLR(P<0.05).Spearman correlation analysis showed that NLR was positively correlated to the necessity of PCI in UAP patients(r=0.353,P<0.001).Multivariate logistic regression analysis indicated that NLR was independent risk factor for PCI in UAP patients(OR=1.982,95%CI 1.168~3.362).ROC curve showed that the area under the curve of NLR in the diagnosis of unstable angina requires PCI treatment was 0.719(95%CI 0.651~0.776).Conclusion NLR can be regarded as one of the predictors for PCI in UAP patients.

关 键 词：中性粒细胞/淋巴细胞比值 不稳定型心绞痛 经皮冠状动脉介入 相关性 

分 类 号：R541.4[医药卫生—心血管疾病]